protein

Recombinant Human Heme Oxygenase 1

MBS143909

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Heme Oxygenase 1

Heme Oxygenase 1

HMOX1 Human; Heme Oxygenase 1 Human Recombinant; HO-1; HSP32; bK286B10; HMOX-1; Heme oxygenase 1; HMOX1; HO; HO1

heme oxygenase 1; Heme oxygenase 1; heme oxygenase 1; heat shock protein, 32-kD; heme oxygenase (decycling) 1

HMOX1

HMOX1; HMOX1; HO-1; HSP32; HMOX1D; bK286B10; HO; HO1; HO-1

HMOX1_HUMAN

E Coli

288

Greater than 95.0% as determined by SDS-PAGE.

HMOX1 1 mg/ml solution containing 20mM Tris-HCl pH-8, 50mM NaCl, 0.1mM PMSF and 10% glycerol. Sterile filtered colorless solution.

ENZYMES; Enzymes; Oxygenase

Description: HO-1 Human Recombinant protein produced in E Coli is a single, non-glycosylated, polypeptide chain containing 274 amino acids (1-266) and having a molecular mass of 31.4 kDa. HO-1 is fused to 8 amino acid His Tag at C-Terminus and purified by proprietary chromatographic techniques. Introduction: HMOX1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is then converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HMOX1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme Oxygenase-1 is involved in the regulation of cardiovascular function and its adaptive response to a variety of stressors. HMOX1 is induced in the colon of ulcerative colitis. HMOX1 is found to overexpress with a higher extent of intraplaque angiogenesis implies a multi-faceted role for HMOX1 in modulating the progression of atherosclerosis. HMOX1 expression reduced LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha in murine and human macrophages.

4504437

NP_002124.1

NM_002133.2

P09601

32,819 Da

HIF-1 Signaling Pathway 695200!!HIF-1-alpha Transcription Factor Network Pathway 138045!!Heme Degradation Pathway 160971!!Iron Uptake And Transport Pathway 187191!!Keap1-Nrf2 Pathway 198777!!Metabolism Pathway 477135!!Metabolism Of Porphyrins Pathway 106325!!MicroRNAs In Cancer Pathway 852705!!MicroRNAs In Cancer Pathway 852928!!Mineral Absorption Pathway 212237

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

0.01 mg

140 USD