protein

Recombinant Human Nicotinamide N-Methyltransferase

MBS143908

1 mg

2665 USD

Recombinant Protein

Recombinant Human Nicotinamide N-Methyltransferase

Nicotinamide N-Methyltransferase

NNMT Human; Nicotinamide N-Methyltransferase Human Recombinant; Nicotineamide N-methyltransferase; NNMT

nicotinamide N-methyltransferase; Nicotinamide N-methyltransferase; nicotinamide N-methyltransferase; nicotinamide N-methyltransferase

NNMT

NNMT; NNMT

NNMT_HUMAN

E Coli

264

MGSSHHHHHH SSGLVPRGSH MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQLLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCVLSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNEGLFSLVARKL SRPL.

Greater than 95.0% as determined by SDS-PAGE.

The NNMT solution contains 20mM Tris pH 8.0 & 20% glycerol. Sterile Filtered colorless solution.

NNMT although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

ENZYMES; Enzymes; Transferase

Description: NNMT Human Recombinant fused with 20 amino acid His-Tag tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing a total of 284 amino acids (1-264 a.a.) and having a molecular mass of 31.7 kDa.The NNMT is purified by proprietary chromatographic techniques. Introduction: NNMT is part of the family of transferases, especially those transferring one-carbon group methyltransferases. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is significant for biotransformation of many drugs and xenobiotic compounds. NNMT is accountable for the enzymatic activity which uses S-adenosyl methionine as the methyl donor. NNMT expression is related with tumor stage and DFS time in hepatocellular carcinoma cases. NNMT is a good candidate as a tumor marker of various kinds of cancers. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.

5453790

NP_006160.1

NM_006169.2

P40261

29,574 Da

Biological Oxidations Pathway 105698!!Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway 1127639!!Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway 1127658!!Defective GGT1 Causes Glutathionuria (GLUTH) Pathway 1127659!!Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway 1127660!!Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway 1127663!!Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway 1127661!!Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway 1127665!!Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway 1127666!!Defective UGT1A1 Causes Hyperbilirubinemia Pathway 1127667

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

1 mg

2665 USD