catalog number :
MBS143898
products type :
Recombinant Protein
products full name :
Recombinant Human Hepatoma-Derived Growth Factor
products short name :
[Hepatoma-Derived Growth Factor]
products name syn :
[High-mobility group protein 1-like 2, HMG1L2, HMG-1L2, Hepatoma-derived growth factor, HDGF, FLJ96580, DKFZp686J1764.]
other names :
[hepatoma-derived growth factor isoform b; Hepatoma-derived growth factor; hepatoma-derived growth factor; HMG-1L2; high mobility group protein 1-like 2; hepatoma-derived growth factor; High mobility group protein 1-like 2; HMG-1L2]
products gene name :
[HDGF]
other gene names :
[HDGF; HDGF; HMG1L2; HMG1L2; HDGF; HMG-1L2]
uniprot entry name :
HDGF_HUMAN
sequence :
MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY
purity :
Greater than 95% as determined by SDS-PAGE.
form :
The HDGF protein solution (1mg/ml) is formulated in 20mM Tris-HCl pH-7.5, 1mM DTT, 10% glycerol and 1mM EDTA.
storage stability :
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
other info1 :
Physical Appearance: Sterile filtered clear solution
products categories :
CYTOKINES AND GROWTH FACTORS; Growth Factors
products description :
The HDGF Human recombinant protein is a single, non-glycosylated polypeptide chain produced in E Coli, having a molecular weight of 11.5kDa and containing 100 amino acids.The HDGF is purified by proprietary chromatographic techniques.
ncbi acc num :
NP_001119522.1
ncbi gb acc num :
NM_001126050.1
ncbi pathways :
IRE1alpha Activates Chaperones Pathway (105906); Metabolism Of Proteins Pathway (106230); Unfolded Protein Response (UPR) Pathway (105904); XBP1(S) Activates Chaperone Genes Pathway (530771)
ncbi summary :
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
uniprot summary :
HDGF: Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. Belongs to the HDGF family. Protein type: Cytokine; Transcription regulation. Chromosomal Location of Human Ortholog: 1q23.1. Cellular Component: nucleoplasm; extracellular space; transcriptional repressor complex; cytoplasm. Molecular Function: heparin binding; DNA binding; growth factor activity; nucleotide binding. Biological Process: cell proliferation; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; transcription, DNA-dependent; unfolded protein response; negative regulation of transcription from RNA polymerase II promoter; signal transduction