protein

Recombinant Human Phosphoribosyl Pyrophosphate Synthetase 1

MBS143889

1 mg

2220 USD

Recombinant Protein

Recombinant Human Phosphoribosyl Pyrophosphate Synthetase 1

Phosphoribosyl Pyrophosphate Synthetase 1

PRPS1 Human; Phosphoribosyl Pyrophosphate Synthetase 1 Human Recombinant; ARTS; CMTX5; PPRibP; PRSI; DFN2; Ribose-phosphate pyrophosphokinase 1; DFNX1; Phosphoribosyl pyrophosphate synthase I; PRS-I; PRPS1; KIAA0967

ribose-phosphate pyrophosphokinase 1 isoform 2; Ribose-phosphate pyrophosphokinase 1; ribose-phosphate pyrophosphokinase 1; dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1); deafness 2, perceptive, congenital; deafness, X-linked 2, perceptive, congenital; phosphoribosyl pyrophosphate synthase I; ribose-phosphate diphosphokinase 1; phosphoribosyl pyrophosphate synthetase 1; PPRibP; Phosphoribosyl pyrophosphate synthase I; PRS-I

PRPS1

PRPS1; PRPS1; ARTS; DFN2; PRSI; CMTX5; DFNX1; PRS-I; PPRibP; PRS-I

PRPS1_HUMAN

E Coli

114

Greater than 90.0% as determined by SDS-PAGE.

The PRPS1 protein solution contains 20mM Tris-HCl, pH-8, 100mM NaCl, 1mM DTT and 20% glycerol. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

PROTEIN KINASES; Enzymes; Synthetase

Description: PRPS1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 338 amino acids (1-318 a.a.) and having a molecular weight of 36.9kDa.The PRPS1 is fused to 20 a.a His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: PRPS1 catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. PRPS1 catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is essential for purine metabolism and nucleotide biosynthesis. Defects in PRPS1 result in phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome.

324711015

NP_001191331.1

NM_001204402.1

P60891

27,526 Da

5-Phosphoribose 1-diphosphate Biosynthesis Pathway 106221!!Biosynthesis Of Amino Acids Pathway 790012!!Biosynthesis Of Amino Acids Pathway 795174!!Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!Disease Pathway 530764!!Glycogen Storage Diseases Pathway 1127581!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Carbohydrates Pathway 106196

This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

1 mg

2220 USD