Recombinant Human Peroxiredoxin-3 | MyBioSource MBS143870 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Peroxiredoxin-3

catalog :

MBS143870

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143870

products type :

Recombinant Protein

products full name :

Recombinant Human Peroxiredoxin-3

products short name :

Peroxiredoxin-3

products name syn :

PRDX3 Human; Peroxiredoxin-3 Human Recombinant; AOP1; MER5; AOP-1; SP-22; PRO1748; MGC24293; MGC104387; PRDX3; Thioredoxin-dependent peroxide reductase mitochondrial; Peroxiredoxin-3; PRX III; Antioxidant protein 1; Protein MER5 homolog; HBC189

other names :

thioredoxin-dependent peroxide reductase, mitochondrial isoform c; Thioredoxin-dependent peroxide reductase, mitochondrial; thioredoxin-dependent peroxide reductase, mitochondrial; antioxidant protein 1; peroxiredoxin III; peroxiredoxin-3; protein MER5 homolog; peroxiredoxin 3; Antioxidant protein 1; AOP-1; HBC189; Peroxiredoxin III; Prx-III; Peroxiredoxin-3; Protein MER5 homolog

products gene name :

PRDX3

other gene names :

PRDX3; PRDX3; AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; prx-III; AOP1; AOP-1; Prx-III

uniprot entry name :

PRDX3_HUMAN

host :

E Coli

sequence length :

198

sequence :

MPAVTQHAPY FKGTAVVNGE FKDLSLDDFK GKYLVLFFYP LDFTFVCPTE IVAFSDKANE FHDVNCEVVA VSVDSHFSHL AWINTPRKNG GLGHMNIALL SDLTKQISRD YGVLLEGSGL ALRGLFIIDP NGVIKHLSVN DLPVGRSVEE TLRLVKAFQY VETHGEVCPA NWTPDSPTIK PSPAASKEYF QKVNQ.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The PRDX3 solution contains 20mM Tris-HCl pH-8, & 10% glycerol. Sterile Filtered colorless solution.

concentration :

1mg/ml

storage stability :

PRDX3 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

other info2 :

Biological Activity: The specific activity was found to be approximately 82-83 pmole/min/ ug.The enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX3 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25 degree C for 1 minute.

products categories :

ENZYMES; Enzymes; Peroxiredoxin

products description :

Description: PRDX3 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 195 amino acids (63-256 a.a.) and having a molecular mass of 21.5 kDa.The PRDX3 is purified by proprietary chromatographic techniques. Introduction: PRDX3 is part of the peroxiredoxin family of antioxidant enzymes, that reduces hydrogen peroxide and alkyl hydroperoxides. PRDX3 is particularly located in the mitochondria and involved in the regulation of cellular redox status by serving as a primary line of defense against H2O2 produced during respiration. PRDX3 is a significant regulator of the abundance of mitochondrial H(2)O(2), which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling. PRDX3 mitochondrial protein is significantly decreased in Alzheimer Disease and Down Syndrome.

ncbi gi num :

695917253

ncbi acc num :

NP_001289201.1

ncbi gb acc num :

NM_001302272.1

uniprot acc num :

P30048

ncbi mol weight :

25,839 Da

ncbi pathways :

Cellular Responses To Stress Pathway (645258); Detoxification Of Reactive Oxygen Species Pathway (1127552); Selenium Pathway (198825); Validated Targets Of C-MYC Transcriptional Activation Pathway (169351)

ncbi summary :

This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

uniprot summary :

PRDX3: Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Belongs to the AhpC/TSA family. Protein type: EC 1.11.1.15; Oxidoreductase. Chromosomal Location of Human Ortholog: 10q25-q26. Cellular Component: mitochondrion; mitochondrial matrix; early endosome; cytoplasm; IkappaB kinase complex; cytosol. Molecular Function: protein C-terminus binding; identical protein binding; protein binding; thioredoxin peroxidase activity; caspase inhibitor activity; alkyl hydroperoxide reductase activity; kinase binding; protein kinase binding. Biological Process: negative regulation of kinase activity; mitochondrion organization and biogenesis; response to lipopolysaccharide; negative regulation of caspase activity; activation of NF-kappaB transcription factor; response to reactive oxygen species; peptidyl-cysteine oxidation; regulation of mitochondrial membrane potential; response to hydrogen peroxide; hydrogen peroxide catabolic process; positive regulation of cell proliferation; myeloid cell differentiation; response to oxidative stress; maternal placenta development; negative regulation of apoptosis

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

3490

more info or order :

MyBioSource product webpage