Recombinant Human Heat Shock 70kDa Protein-8 | MyBioSource MBS143868 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Heat Shock 70kDa Protein-8

catalog :

MBS143868

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143868

products type :

Recombinant Protein

products full name :

Recombinant Human Heat Shock 70kDa Protein-8

products short name :

Heat Shock 70kDa Protein-8

products name syn :

HSPA8 Human; Heat Shock 70kDa Protein-8 Human Recombinant; LAP1; HSC54; HSC70; HSC71; HSP1; HSP73; NIP71; HSPA10; MGC29929; MGC131511; HSPA8; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8

other names :

heat shock cognate 71 kDa protein isoform 1; Heat shock cognate 71 kDa protein; heat shock cognate 71 kDa protein; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; heat shock 70kd protein 10; heat shock cognate protein 54; lipopolysaccharide-associated protein 1; heat shock 70kDa protein 8; Heat shock 70 kDa protein 8; Lipopolysaccharide-associated protein 1; LAP-1; LPS-associated protein 1

products gene name :

HSPA8

other gene names :

HSPA8; HSPA8; LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p; HSC70; HSP73; HSPA10; LAP-1; LPS-associated protein 1

uniprot entry name :

HSP7C_HUMAN

host :

E Coli

sequence length :

646

sequence :

MGSSHHHHHH SSGLVPRGSH MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH FIAEFKRKHK KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA RFEELNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL QDFFNGKELN KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS LGIETAGGVM TVLIKRNTTI PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI DANGILNVSA VDKSTGKENK ITITNDKGRL SKEDIERMVQ EAEKYKAEDE KQRDKVSSKN SLESYAFNMK ATVEDEKLQG KINDEDKQKI LDKCNEIINW LDKNQTAEKE EFEHQQKELE KVCNPIITKL YQSAGGMPGG MPGGFPGGGA PPSGGASSGP TIEEVD.

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

The HSC70 protein solution contains 20mM Tris, pH-8 & 10% Glycerol. Sterile filtered colorless solution.

concentration :

1mg/ml

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

HEAT SHOCK PROTEINS; Recombinant Proteins; Heat Shock Protein

products description :

Description: Recombinant Human HSC70 produced in E Coli is a single, non-glycosylated polypeptide chain containing 666 amino acids (1-646 a.a.) and having a molecular mass of 73.1kDa.HSC70 human recombinant is fused to 20 amino acid His Tag at N-terminus and purified by convential chromatogrpahy techniques. Introduction: HSPA8 is part of the heat shock protein 70 family which includes both heat-inducible and constitutively expressed proteins (heat-shock cognate proteins). HSPA8 is a heat-shock cognate protein that binds to nascent polypeptides to facilitate correct folding. HSPA8 plays a role as an ATPase in the disassembly of clathrin-coated vesicles through transport of membrane components through the cell. HSPA8 is expressed in colon cancer cells, HSPA8 takes part in reovirus outer capsid disassembly, through membrane penetration, to plan the entering particle for gene expression and replication. serum HSPA8 concentrations are reduced in normal human pregnancy. HSPA8 plays a role in androgen action on dermal papilla cells. HSPA8 is directly linked with Influenza virus matrix protein 1 and thus required for viral production.

ncbi gi num :

5729877

ncbi acc num :

NP_006588.1

ncbi gb acc num :

NM_006597.5

uniprot acc num :

P11142

ncbi mol weight :

53,518 Da

ncbi pathways :

AUF1 (hnRNP D0) Destabilizes MRNA Pathway (187212); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Attenuation Phase Pathway (1127556); Axon Guidance Pathway (105688); C-MYB Transcription Factor Network Pathway (138073); CHL1 Interactions Pathway (161007); Cellular Response To Heat Stress Pathway (1127553); Cellular Responses To Stress Pathway (645258); Clathrin Derived Vesicle Budding Pathway (119545)

ncbi summary :

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

uniprot summary :

HSC70: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Chaperone; RNA-binding; Nucleolus; Heat shock protein. Chromosomal Location of Human Ortholog: 11q24.1. Cellular Component: nucleoplasm; spliceosome; extracellular space; focal adhesion; membrane; melanosome; plasma membrane; nucleolus; intracellular; nucleus; ribonucleoprotein complex; cytosol; ubiquitin ligase complex. Molecular Function: protein binding; enzyme binding; G-protein-coupled receptor binding; heat shock protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATPase activity; ATPase activity, coupled; ATP binding. Biological Process: axon guidance; chaperone cofactor-dependent protein folding; viral reproduction; transcription, DNA-dependent; protein folding; regulation of cell cycle; RNA splicing; neurotransmitter secretion; response to unfolded protein; nuclear mRNA splicing, via spliceosome; positive regulation of nuclear mRNA splicing, via spliceosome; synaptic transmission; gene expression; protein refolding; post-Golgi vesicle-mediated transport; negative regulation of transcription, DNA-dependent

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage