Recombinant Human Transforming Growth Factor Beta Receptor II | MyBioSource MBS143856 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Transforming Growth Factor Beta Receptor II

catalog :

MBS143856

quantity :

0.01 mg

price :

205 USD

product information

catalog number :

MBS143856

products type :

Recombinant Protein

products full name :

Recombinant Human Transforming Growth Factor Beta Receptor II

products short name :

Transforming Growth Factor Beta Receptor II

products name syn :

TGFBR2 Human; Transforming Growth Factor Beta Receptor II Human Recombinant; AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGFBR-2; TGF-beta receptor type-2; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TGF-beta type II receptor; TbetaR-II; TGFBR2

other names :

TGF-beta receptor type-2 isoform A; TGF-beta receptor type-2; TGF-beta receptor type-2; TGF-beta receptor type IIB; TGF-beta type II receptor; tbetaR-II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II (70/80kDa); TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II

products gene name :

TGFBR2

other gene names :

TGFBR2; TGFBR2; AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGFR-2; TGF-beta receptor type II; TbetaR-II

uniprot entry name :

TGFR2_HUMAN

host :

E Coli

sequence length :

592

sequence :

HVQK SVNNDMIVTD NNGAVKFPQL CKFCDVRFST CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDAASPK CIMKEKKKPG ETFFMCSCSS DECNDNIIFS EEYNTSNPD

purity :

Greater than 97.0% as determined by SDS-PAGE.

form :

Lyophilized from a 0.2 um filtered solution in buffer containing 150mM NaCl & 50mM sodium phosphate buffer pH-7.5. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized TGFBR2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TGFBR2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Patent Rights: The sale and/or commercial use of Recombinant Human Transforming Growth Factor Beta Receptor II (TGFBR2) is prohibited in the United States of America (U.S.A). Solubility: It is recommended to reconstitute the lyophilized TGFBR2 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Activity: In ELISA assay, concentrations 0.5-1 ug/ml can be used for TGF-beta measurements

products categories :

PROTEIN KINASES; Enzymes; Protein Kinases

products description :

Description: TGFBR2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain encoding 133 amino acids (27-159 a.a.), the extracellular domain of TGFBR2, having a molecular mass of 15.1 kDa.TGFBR2 is purified by proprietary chromatographic techniques. Introduction: TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer.

ncbi gi num :

67782326

ncbi acc num :

NP_001020018.1

ncbi gb acc num :

NM_001024847.2

uniprot acc num :

P37173

ncbi mol weight :

67,457 Da

ncbi pathways :

ALK1 Signaling Events Pathway 137968!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chronic Myeloid Leukemia Pathway 83116!!Chronic Myeloid Leukemia Pathway 528!!Colorectal Cancer Pathway 83106!!Colorectal Cancer Pathway 518!!Cytokine-cytokine Receptor Interaction Pathway 83051

ncbi summary :

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

size :

0.01 mg

price :

205 USD