protein

Recombinant Human Transthyretin

MBS143854

1 mg

2220 USD

Recombinant Protein

Recombinant Human Transthyretin

Transthyretin

Transthyretin Human; Prealbumin Human Recombinant; TTHY; TTR; ATTR; TBPA; Transthyretin; Prealbumin; PALB; HsT2651; Prealbumin

transthyretin; Transthyretin; transthyretin; ATTR; carpal tunnel syndrome 1; epididymis luminal protein 111; prealbumin, amyloidosis type I; thyroxine-binding prealbumin; transthyretin; ATTR; Prealbumin; TBPA

TTR; TTR; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; PALB

TTHY_HUMAN

E Coli

147

MGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGELHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKE.

Greater than 95.0% as determined by SDS-PAGE.

The Transthyertin protein solution contains 1x PBS, pH-7.4, and 10% glycerol. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Albumin

Description: Transthyertin Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 128 amino acids (21-147 a.a.) and having a molecular weight of 13.8kDa. The Transthyertin is purified by proprietary chromatographic techniques. Introduction: Prealbumin is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. Prealbumin is a carrier protein which transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Transthyretin consists of a tetramer of identical subunits and is dominantly produced in the liver. Mutations in Prealbumin are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. Prealbumin is an indicator of protein-energy malnutrition since it has a circulating half life of 2 days and reacts swiftly to changes in nutritional status.

4507725

NP_000362.1

NM_000371.3

P02766

15,887 Da

Amyloids Pathway 366238!!Disease Pathway 530764!!Diseases Associated With Visual Transduction Pathway 771581!!Extracellular Matrix Organization Pathway 576262!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911!!Non-integrin Membrane-ECM Interactions Pathway 833810!!Retinoid Cycle Disease Events Pathway 771582!!Retinoid Metabolism And Transport Pathway 187208!!Signal Transduction Pathway 477114!!The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway 771585

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]

1 mg

2220 USD