Recombinant Human Retinoic Acid Receptor Responder 2 | MyBioSource MBS143851 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Retinoic Acid Receptor Responder 2

catalog :

MBS143851

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143851

products type :

Recombinant Protein

products full name :

Recombinant Human Retinoic Acid Receptor Responder 2

products short name :

Retinoic Acid Receptor Responder 2

products name syn :

RARRES2 Human; Retinoic Acid Receptor Responder 2 Human Recombinant; Chemerin; TIG2; Tazarotene-induced gene 2 protein; Retinoic acid receptor responder protein 2; RAR-responsive protein TIG2; RARRES2; HP10433

other names :

retinoic acid receptor responder protein 2; Retinoic acid receptor responder protein 2; retinoic acid receptor responder protein 2; RAR-responsive protein TIG2; chemerin; tazarotene-induced gene 2 protein; retinoic acid receptor responder (tazarotene induced) 2; Chemerin; RAR-responsive protein TIG2; Tazarotene-induced gene 2 protein

products gene name :

RARRES2

other gene names :

RARRES2; RARRES2; TIG2; HP10433; TIG2

uniprot entry name :

RARR2_HUMAN

host :

E Coli

sequence length :

163

sequence :

MELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAAVDTP FPAGIFVRLE FKLQQTSRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFS.

purity :

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The RARRES2 protein was lyophilized from 0.02% TFA. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Chemerin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Chemerin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Chemerin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: RARRES2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 138 amino acids and having a total molecular mass of 16 kDa. RARRES2 Human Recombinant is purified by proprietary chromatographic techniques. Introduction: RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 is upregulated by the synthetic retinoid tazarotene and found in a vast variety of tissues. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains. The Chemerin receptor has another ligand, called tazarotene-induced gene

ncbi gi num :

4506427

ncbi acc num :

NP_002880.1

ncbi gb acc num :

NM_002889.3

uniprot acc num :

Q99969

ncbi mol weight :

18,618 Da

ncbi summary :

This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]

uniprot summary :

RARRES2: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 7q36.1. Cellular Component: extracellular matrix; extracellular region. Molecular Function: protein binding; receptor binding. Biological Process: positive regulation of chemotaxis; in utero embryonic development; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation; inflammatory response; retinoid metabolic process; chemotaxis; embryonic gut development; regulation of lipid catabolic process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage