Recombinant Human Ubiquitin Aldehyde Binding 1 | MyBioSource MBS143848 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Ubiquitin Aldehyde Binding 1

catalog :

MBS143848

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143848

products type :

Recombinant Protein

products full name :

Recombinant Human Ubiquitin Aldehyde Binding 1

products short name :

Ubiquitin Aldehyde Binding 1

products name syn :

OTUB1 Human; Ubiquitin Aldehyde Binding 1 Human Recombinant; Ubiquitin thioesterase OTUB1; Otubain-1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Ubiquitin-specific-processing protease OTUB1; Deubiquitinating enzyme OTUB1; OTUB1; OTB1; OTU1; HSPC263; MGC4584; FLJ20113; FLJ40710; MGC111158

other names :

ubiquitin thioesterase OTUB1; Ubiquitin thioesterase OTUB1; ubiquitin thioesterase OTUB1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU-domain Ubal-binding 1; deubiquitinating enzyme OTUB1; otubain-1; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1; OTU deubiquitinase, ubiquitin aldehyde binding 1; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; hOTU1; Ubiquitin-specific-processing protease OTUB1

products gene name :

OTUB1

other gene names :

OTUB1; OTUB1; OTB1; OTU1; HSPC263; OTB1; OTU1; hOTU1

uniprot entry name :

OTUB1_HUMAN

host :

E Coli

sequence length :

271

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The OTUB1 solution contains 20mM Tris buffer (pH 8.0) and 10% glycerol. Sterile Filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Ubiquitin

products description :

Description: OTUB1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 291 amino acids (1- 271 a.a.) and having a molecular mass of 33.4kDa.The OTUB1 is purified by proprietary chromatographic techniques. Introduction: Otubain 1 (OTUB1) belongs to the ovarian tumor (OUT) superfamily of predicted cysteine proteases and inhibits cytokine gene transcription in the immune system through its interaction with a ubiquitin protease and E3 ubiquitin ligase. OTUB1 is a highly specific ubiquitin iso-peptidase, it cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. OTUB1 is believed to work in specific ubiquitin-dependent pathways, possibly by providing an editing function of polyubiquitin chain growth. OTUB1 is a hydrolase that removes conjugated ubiquitin from proteins in vitro and may therefore have a significant regulatory role in the level of protein turnover by preventing degradation. Additionally, OTUB1 is a regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered impassive to antigen re-challenge and no longer respond to their cognate antigen. OTUB1 acts via its interaction with RNF128/GRAIL, which is an essential inductor of CD4 T-cell anergy.

ncbi gi num :

109148508

ncbi acc num :

NP_060140.2

ncbi gb acc num :

NM_017670.2

uniprot acc num :

Q96FW1

ncbi mol weight :

35,285 Da

ncbi summary :

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

uniprot summary :

OTUB1: a protease that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occur when T-cell are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Two alternatively spliced isoforms are known. Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Protease; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 11q13.1. Cellular Component: cytoplasm. Molecular Function: protein binding; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity; NEDD8-specific protease activity. Biological Process: immune system process; proteolysis; DNA repair; response to DNA damage stimulus

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage