protein

Recombinant Human Galectin-7 His Tag

MBS143847

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Galectin-7 His Tag

Galectin-7

LGALS7 Human, His; Galectin-7 Human Recombinant, His Tag; Galectin-7; Gal-7; HKL-14; PI7; p53-induced gene 1 protein; LGALS7; PIG1; LGALS7B; GAL7; LGALS7A; LGALS7 His

galectin-7; Galectin-7; galectin-7; galectin 7B; galectin-7B; keratinocyte lectin 14; lectin galactoside-binding soluble 7; p53-induced gene 1 protein; p53-induced protein 1; lectin, galactoside-binding, soluble, 7B; HKL-14; PI7; p53-induced gene 1 protein

LGALS7

LGALS7B; LGALS7; PI7; GAL7; Gal-7; HKL-14; LGALS7; PIG1; Gal-7

LEG7_HUMAN

E Coli

136

Greater than 95.0% as determined by SDS-PAGE.

The Galectin-7 solution (1 mg/ml) 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 1mM DTT. Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

CYTOKINES AND GROWTH FACTORS; Growth Factors; Galectin

Description: Galectin-7 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 156 amino acids (1-136 a.a.) and having a molecular mass of 17.2kDa. The Galectin-7 is purified by proprietary chromatographic techniques. Introduction: Galectins are a family of animal lectins with an affinity for beta-galactosides. This family has at least 14 identified members. Galectins share similarities in the CRD (the carbohydrate recognition domain). Galectins are synthesized as cytosolic proteins. Though localized principally in the cytoplasm and lacking a classical signal peptide, galectins can also be stimulated to secretion by non-classical pathways or alternatively targeted to the nucleus. Galectins are involved in modulating cell-cell and cell-matrix interactions. Human Galectin-7 belongs to the prototypical Galectins containing a single CRD, which is initially identified in human epidermis as a monomer. The Galectin-7 expression is induced by tumor suppressor protein p53 and associated with apoptosis. Galectin-7 is a pro-apoptotic protein which functions intracellularlly upstream of JNK activation and mitochondrial cytochrome c release. The correlation of Galectin-7 with the UV-induced apoptosis of keratinocytes presents a critical mechanism in the maintenance of epidermal homeostasis. Human Galectin-7 is localized in both nucleus and cytoplasm.

109948279

NP_001035972.1

NM_001042507.3

P47929

15,075 Da

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]

LGALS7B: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. Protein type: Apoptosis; Cell adhesion. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: extracellular space; cytoplasm; nucleus. Molecular Function: carbohydrate binding. Biological Process: heterophilic cell adhesion; apoptosis

0.005 mg

140 USD

0.02 mg

205

1 mg

2665