protein

Recombinant Human Visinin-Like Protein-1

MBS143824

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Visinin-Like Protein-1

Visinin-Like Protein-1

VSNL1 Human; Visinin-Like Protein-1 Human Recombinant; VISL1; VISL-1; VIS1; VIS-1; VILIP; HLP3; Hippocalcin-like protein 3; VSNL1; VILIP-1; VILIP1; HLP-3; HPCAL3; HUVISL1; Visinin-like protein 1

visinin-like protein 1; Visinin-like protein 1; visinin-like protein 1; VLP-1; hippocalcin-like protein 3; visinin-like 1; Hippocalcin-like protein 3; HLP3

VSNL1

VSNL1; VSNL1; HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1; VISL1; VILIP; VLP-1; HLP3

VISL1_HUMAN

E Coli

191

MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K.

Greater than 95.0% as determined by SDS-PAGE.

The VSNL1 protein solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT and 10% glycerol.

1mg/ml

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Physical Appearance : Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Visinin-Like Protein

Description: VSNL1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 191 amino acids (1-191 a.a.) and having a molecular mass of 22.1kDa.The VSNL1 is purified by proprietary chromatographic techniques. Introduction: VSNL1 is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. VILIP1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Changes in cellular expression of VSNL1 were found in hipppocampi of schizophrenics, since more interneurons showed immunoreactivity. VILIP1 is expressed in pancreatic beta-cells. VILIP1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription. VILIP-1 interacts with cell membrane and actin-based cytoskeleton. VSNL1 modulates cAMP-accumulation in C6 glioma cells. HLP3 modulates cGMP-accumulation in transfected neural cells and cerebellar granule neurons.

21361559

NP_003376.2

NM_003385.4

P62760

22,142 Da

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

VSNL1: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. Belongs to the recoverin family. Chromosomal Location of Human Ortholog: 2p24.3. Molecular Function: calcium ion binding. Biological Process: calcium-mediated signaling

0.01 mg

140 USD

0.05 mg

205

1 mg

1790