protein

Recombinant Human Tubulin Folding Cofactor A

MBS143821

1 mg

2665 USD

Recombinant Protein

Recombinant Human Tubulin Folding Cofactor A

Tubulin Folding Cofactor A

TBCA Human; Tubulin Folding Cofactor A Human Recombinant; Tubulin-specific chaperone A; Tubulin-folding cofactor A; CFA; TCP1-chaperonin cofactor A; TBCA

tubulin-specific chaperone A isoform 1; Tubulin-specific chaperone A; tubulin-specific chaperone A; CFA; TCP1-chaperonin cofactor A; tubulin-folding cofactor A; tubulin folding cofactor A; TCP1-chaperonin cofactor A; Tubulin-folding cofactor A; CFA

TBCA

TBCA; TBCA; CFA

TBCA_HUMAN

E Coli

129

MADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI KKQAEILQES RMMIPDCQRR LEAAYLDLQR ILENEKDLEE AEEYKEARLV LDSVKLEA.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The TBCA solution contains 20mM Tris-HCl buffer pH 7.5, 1mM DTT and 10% glycerol. Sterile Filtered colorless solution.

TBCA although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Tubulin Folding Cofactor

Description: TBCA Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids (1-108 a.a.) and having a molecular mass of 12.8 kDa.The TBCA is purified by proprietary chromatographic techniques. Introduction: TBCA is a tubulin-folding protein which is involved in the early step of the tubulin folding pathway. TBCA is one of four proteins (cofactors A, D, E, and C) implicated in the pathway directing to properly folded beta-tubulin from folding intermediates. Cofactors A and D are thought to be a factor in capturing and stabilizing beta-tubulin in a quasi-native confirmation. TBCA is crucial for cell viability, if reduced it causes a decrease in the amount of soluble tubulin, alterations in microtubules and G1 cell cycle arrest. Cofactor E attaches to the cofactor D-tubulin complex, afterward, interaction with cofactor C triggers the release of tubulin polypeptides that are committed to the native state.

663071149

NP_001284667.1

NM_001297738.1

O75347

15,792 Da

Metabolism Of Proteins Pathway 106230!!Post-chaperonin Tubulin Folding Pathway 106248!!Protein Folding Pathway 106241

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

1 mg

2665 USD