Recombinant Human Aldehyde Dehydrogenase 3 A1 | MyBioSource MBS143817 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Aldehyde Dehydrogenase 3 A1

catalog :

MBS143817

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143817

products type :

Recombinant Protein

products full name :

Recombinant Human Aldehyde Dehydrogenase 3 A1

products short name :

Aldehyde Dehydrogenase 3 A1

products name syn :

ALDH3A1 Human; Aldehyde Dehydrogenase 3 Family Member A1 Human Recombinant; Aldehyde dehydrogenase 3 family member A1; aldehyde dehydrogenase; dimeric NADP-preferring; ALDH-3; aldehyde dehydrogenase isozyme; ALDHIII; MGC104062; aldehyde dehydrogenase type III; Aldehyde dehydrogenase; stomach aldehyde dehydrogenase; EC 1.2.1.53; aldehyde dehydrogenase 3A; Aldehyde dehydrogenase

other names :

aldehyde dehydrogenase, dimeric NADP-preferring; Aldehyde dehydrogenase, dimeric NADP-preferring; aldehyde dehydrogenase, dimeric NADP-preferring; aldehyde dehydrogenase isozyme 3; aldehyde dehydrogenase type III; stomach aldehyde dehydrogenase; aldehyde dehydrogenase 3 family, member A1; ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1

products gene name :

ALDH3A1

other gene names :

ALDH3A1; ALDH3A1; ALDH3; ALDHIII; ALDH3

uniprot entry name :

AL3A1_HUMAN

host :

E Coli

sequence length :

453

purity :

Greater than 95% as determined by SDS-PAGE.

form :

ALDH3A1 solution containing 20mM Tris-HCl pH-8, 0.1M NaCl and 10% glycerol. Sterile filtered colorless solution.

other info2 :

Biological Activity: Specific activity was found to be < 1 units/ml. Activity was obtained by measuring the increase of NADP in absorbance at 340 nm resulting from the reduction of NAD. 1 unit will oxidize 1umole of acetaldehyde to acetic acid per minute at pH 8 at 25 degree C in the presence of beta-NAD, potassium and thiols.

products categories :

ENZYMES; Enzymes; Dehydrogenase

products description :

Description: ALDH3A1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 473 amino acids (1-453 a.a.) and having a molecular mass of 52.5 kDa. ALDH3A1 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: ALDH3A1 is involved in the detoxification of alcohol-derived acetaldehyde. ALDH3A1 participates in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 oxidizes aromatic aldehyde substrates and toxic aldehydes. ALDH3A1 forms a cytoplasmic homodimer that oxidizes aromatic and medium-chain saturated and unsaturated aldehyde substrates. ALDH3A1 promotes resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea.

ncbi gi num :

22907049

ncbi acc num :

NP_000682.3

ncbi gb acc num :

NM_000691.4

uniprot acc num :

P30838

ncbi mol weight :

50,395 Da

ncbi pathways :

2'-deoxy-alpha-D-ribose 1-phosphate Degradation Pathway (1108781); AhR Pathway (755436); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Drug Metabolism - Cytochrome P450 Pathway (83032); Drug Metabolism - Cytochrome P450 Pathway (427); Glycolysis / Gluconeogenesis Pathway (82926); Glycolysis / Gluconeogenesis Pathway (287); Histidine Metabolism Pathway (82958); Histidine Metabolism Pathway (324)

ncbi summary :

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

uniprot summary :

ALDH3A1: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. Belongs to the aldehyde dehydrogenase family. Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - histidine; Oxidoreductase; EC 1.2.1.5; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Xenobiotic Metabolism - metabolism by cytochrome P450. Chromosomal Location of Human Ortholog: 17p11.2. Cellular Component: nucleoplasm; extracellular space; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; plasma membrane; cytosol. Molecular Function: aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity; alcohol dehydrogenase (NADP+) activity. Biological Process: response to drug; response to cAMP; positive regulation of cell proliferation; response to glucocorticoid stimulus; response to hypoxia; aldehyde metabolic process; response to nutrient; aging

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage