protein

Recombinant Human N-Myc Downstream Regulated 1

MBS143793

0.01 mg

140 USD

Recombinant Protein

Recombinant Human N-Myc Downstream Regulated 1

N-Myc Downstream Regulated 1

NDRG1 Human; N-Myc Downstream Regulated 1 Human Recombinant; Protein NDRG1; N-myc downstream-regulated gene 1 protein; Differentiation-related gene 1 protein; Reducing agents and tunicamycin-responsive protein; Nickel-specific induction protein Cap43; DRG-1; RTP; Rit42; NDRG1; CAP43; DRG1; GC4; NDR1; NMSL; TDD5; CMT4D; HMSNL; TARG1; PROXY1

protein NDRG1 isoform 1; Protein NDRG1; protein NDRG1; N-myc downstream-regulated gene 1 protein; differentiation-related gene 1 protein; nickel-specific induction protein Cap43; protein regulated by oxygen-1; reducing agents and tunicamycin-responsive protein; N-myc downstream regulated 1; Differentiation-related gene 1 protein; DRG-1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42

NDRG1

NDRG1; NDRG1; GC4; RTP; DRG1; NDR1; NMSL; TDD5; CAP43; CMT4D; DRG-1; HMSNL; RIT42; TARG1; PROXY1; CAP43; DRG1; RTP; DRG-1; RTP

NDRG1_HUMAN

E Coli

394

Greater than 95.0% as determined by SDS-PAGE.

The NDRG1 solution contains 20mM Tris-HCl buffer (pH8.0), 0.1mM PMSF and 10% Glycerol. Sterile Filtered colorless solution.

Biological Activity: Measured in a cell proliferation assay using MCF7 cell. The ED50 for this effect is 0.5 - 1.5ng/ml, corresponding to a Specific Activity of 666,000 -2,000,000 IU/mg.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; N-Myc Downstream Regulated

Description: NDRG1 Human Recombinant fused with 8 amino acid His tag at C-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 402 amino acids (1-394 a.a.) and having a molecular mass of 43.9 kDa.The NDRG1 is purified by proprietary chromatographic techniques. Introduction: NDRG1 is a cytoplasmic protein that is involved in stress responses, hormone responses, cell growth, and differentiation. NDRG1 is one of 4 members of the NDRG ?/?-hydrolase family. NDRG1 is classified in databases as a tumor suppressor and heavy metal-response protein. NDRG1's functions include cell-cycle regulation, cellular differentiation, apoptosis, hypoxia response and metal-ion sensing. NDRG1 is also essential for p53-mediated caspase activation and apoptosis. The NDRG1 is a Rab4a effector that is involved in vesicular recycling of E-cadherin. NDRG1 is ubiquitous; it is expressed most notably in placental membranes and prostate, kidney, small intestine, and ovary tissues. NDRG1 has reduced expression in adenocarcinomas compared to normal tissues. NDRG1 gene mutations are reported to be the cause for hereditary motor and sensory neuropathy-Lom (HMSNL), which is a severe autosomal recessive form of Charcot- Marie-Tooth (CMT) disease. In addition, decreased NDRG1 expression in glioma is linked to tumor progression. On the other hand, overexpression of NDRG1 is connected to malignant status of esophageal cancer. NDRG1 may also have a role in portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma.

207028748

NP_001128714.1

NM_001135242.1

Q92597

33,650 Da

Direct P53 Effectors Pathway 137939!!HIF-1-alpha Transcription Factor Network Pathway 138045!!Prostate Cancer Pathway 755440!!Validated Targets Of C-MYC Transcriptional Repression Pathway 169353

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

0.01 mg

140 USD