protein

Recombinant Human General Transcription Factor IIB

MBS143789

0.005 mg

140 USD

Recombinant Protein

Recombinant Human General Transcription Factor IIB

General Transcription Factor IIB

GTF2B Human; General Transcription Factor IIB Human Recombinant; TF2B; TFIIB; GTF2B; Transcription initiation factor IIB; General transcription factor TFIIB; S300-II

transcription initiation factor IIB; Transcription initiation factor IIB; transcription initiation factor IIB; RNA polymerase II transcription factor IIB; S300-II; general transcription factor TFIIB; general transcription factor IIB; General transcription factor TFIIB; S300-II

GTF2B

GTF2B; GTF2B; TF2B; TFIIB; TF2B; TFIIB

TF2B_HUMAN

E Coli

316

Greater than 90.0% as determined by SDS-PAGE.

The GTF2B solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 20% glycerol. Sterile Filtered clear solution.

0.5mg/ml

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; General Transcription Factor

Description: GTF2B Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 336 amino acids (1-316 a.a.) and having a molecular mass of 36.9 kDa. The GTF2B is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: GTF2B is one of the ubiquitous factors needed for transcription initiation by RNA polymerase II preinitiation factor. GTF2B localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. GTF2 plays a role as a bridge between IID, which initially recognizes the promoter sequence, and RNA polymerase II. GTF2B is involved in the selection of the transcription start site.

4504193

NP_001505.1

NM_001514.5

Q00403

34,833 Da

Basal Transcription Factors Pathway (83038); Basal Transcription Factors Pathway (443); Disease Pathway (530764); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Eukaryotic Transcription Initiation Pathway (198917); Gene Expression Pathway (105937); HIV Infection Pathway (105983); HIV Life Cycle Pathway (105984); HIV Transcription Initiation Pathway (105998)

This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

GTF2B: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Associates with TFIID-IIA (DA complex) to form TFIID-IIA- IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1. Interacts with Epstein-Barr virus EBNA2. Belongs to the TFIIB family. Protein type: Nuclear receptor co-regulator; Transcription factor; Acetyltransferase. Chromosomal Location of Human Ortholog: 1p22-p21. Cellular Component: nucleoplasm; nucleolus; nucleus. Molecular Function: protein binding; zinc ion binding; TATA-binding protein binding; thyroid hormone receptor binding; transcription factor binding. Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; gene expression

0.005 mg

140 USD

0.025 mg

205

1 mg

2220