Recombinant Human Carbonyl Reductase-1 | MyBioSource MBS143784 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Carbonyl Reductase-1

catalog :

MBS143784

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143784

products type :

Recombinant Protein

products full name :

Recombinant Human Carbonyl Reductase-1

products short name :

Carbonyl Reductase-1

products name syn :

CBR1 Human; Carbonyl Reductase-1 Human Recombinant; CBR; hCBR1; SDR21C1; CBR1; Carbonyl reductase [NADPH] 1; NADPH-dependent carbonyl reductase 1; Prostaglandin-E(2) 9-reductase; Prostaglandin 9-ketoreductase; 15-hydroxyprostaglandin dehydrogenase [NADP+]; CRN

other names :

carbonyl reductase; Carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; 15-hydroxyprostaglandin dehydrogenase; NADPH-dependent carbonyl reductase 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; short chain dehydrogenase/reductase family 21C, member 1; carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189)

products gene name :

CBR1

other gene names :

CBR1; CBR1; CBR; hCBR1; SDR21C1; CBR; CRN

uniprot entry name :

CBR1_HUMAN

host :

E Coli

sequence length :

173

sequence :

MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET PVYLALLPPD AEGPHGQFVS EKRVEQW.

purity :

Greater than 95.0% as determined by analysis by SDS-PAGE.

form :

The CBR1 protein contains 20mM Tris-HCl buffer pH-8.5, and 10% glycerol. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

ENZYMES; Enzymes; Reductase

products description :

Description: Recombinant Human CBR1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 277 amino acids (1-277 a.a) and having a molecular mass of 30 kDa. CBR1 is purified by proprietary chromatographic techniques. Introduction: CBR1 is one of numerous monomeric, NADPH-dependent oxidoreductases having ubiquistly specificity for carbonyl compounds. CBR1 is broadly distributed in human tissues. CBR1 metabolizes toxic environmental quinones and pharmacological relevant substrates such as the anticancer doxorubicin. CBR1 converts prostaglandin E2 to prostaglandin F2-alpha.

ncbi gi num :

557948119

ncbi acc num :

NP_001273718.1

ncbi gb acc num :

NM_001286789.1

uniprot acc num :

P16152

ncbi mol weight :

18,762 Da

ncbi pathways :

Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (425)

ncbi summary :

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

uniprot summary :

CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Protein type: EC 1.1.1.184; Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.1.1.189; EC 1.1.1.197. Chromosomal Location of Human Ortholog: 21q22.13. Cellular Component: cytosol; vesicle. Molecular Function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity; 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity. Biological Process: epithelial cell differentiation; vitamin K metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; drug metabolic process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage