protein

Recombinant Human STIP1 Homology and U-Box Containing Protein 1

MBS143772

0.01 mg

140 USD

Recombinant Protein

Recombinant Human STIP1 Homology and U-Box Containing Protein 1

STIP1 Homology and U-Box Containing Protein 1

STUB1 Human; STIP1 Homology and U-Box Containing Protein 1 Human Recombinant; CHIP; UBOX1; HSPABP2; NY-CO-7; SDCCAG7; STUB1; STIP1 homology and U box-containing protein 1; Carboxy terminus of Hsp70-interacting protein; E3 ubiquitin-protein ligase CHIP; CLL-associated antigen KW-8; Antigen NY-CO-7

E3 ubiquitin-protein ligase CHIP isoform b; E3 ubiquitin-protein ligase CHIP; E3 ubiquitin-protein ligase CHIP; CLL-associated antigen KW-8; antigen NY-CO-7; carboxy terminus of Hsp70-interacting protein; heat shock protein A binding protein 2 (c-terminal); serologically defined colon cancer antigen 7; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; Antigen NY-CO-7; CLL-associated antigen KW-8; Carboxy terminus of Hsp70-interacting protein; STIP1 homology and U box-containing protein 1

STUB1

STUB1; STUB1; CHIP; UBOX1; SCAR16; HSPABP2; NY-CO-7; SDCCAG7

CHIP_HUMAN

E Coli

231

MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV EDY.

Greater than 90.0% as determined by SDS-PAGE.

The STUB1 protein solution contains 20mM Tris-HCl, pH-7.5, 10% glycerol and 5mM DTT. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

HEAT SHOCK PROTEINS; Recombinant Proteins; Heat Shock Protein

Description: STUB1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 303 amino acids and having a molecular mass of 34.8 kDa.STUB1 is expressed and purified by proprietary chromatographic techniques. Introduction: STUB1, is a cytoplasmic protein whose amino acid sequence is highly preserved across species. STUB1 interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, whereas its U-box domain contains its E3 ubiquitin ligase activity. STUB1 interaction with these molecular chaperones lead to in client substrate ubiquitylation and degradation by the proteasome. therefore, STUB1 acts to tilt the folding-refolding mechanism towards the degradative pathway, and it serves as a link between the two. STUB1 inhibits anchorage-independent cell growth and metastatic potential by degrading oncogenic proteins including SRC-3. Inhibition of tyrosine kinase activity of Her-2/neu by quercetin specifies an lateration in the Her-2/neu structure which promotes STUB1 recruitments and down-regulation of Her-2/neu. STUB1 recognizes and mediates degradation of toxic, oligomeric forms of alphaSyn.

645912990

NP_001280126.1

NM_001293197.1

Q9UNE7

27,067 Da

Adaptive Immune System Pathway 366160!!Alpha-synuclein Signaling Pathway 137913!!Androgen Receptor Signaling Pathway 198806!!Antigen Processing: Ubiquitination Proteasome Degradation Pathway 366162!!Class I MHC Mediated Antigen Processing Presentation Pathway 366161!!Disease Pathway 530764!!Downregulation Of TGF-beta Receptor Signaling Pathway 645293!!Immune System Pathway 106386!!Loss Of Function Of SMAD2/3 In Cancer Pathway 906019!!Loss Of Function Of SMAD4 In Cancer Pathway 906017

This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

0.01 mg

140 USD