catalog number :
MBS143761
products type :
Recombinant Protein
products full name :
Recombinant Human Polyadenylate-Binding Protein-Interacting Protein 2
products short name :
Polyadenylate-Binding Protein-Interacting Protein 2
products name syn :
PAIP2 Human; Polyadenylate-Binding Protein-Interacting protein 2 Human Recombinant; Poly(A) Binding Protein Interacting Protein 2; PABP- interacting protein 2; HSPC218; PAIP-2; PAIP2A; Polyadenylate-binding protein-interacting protein 2; PAIP2; MGC72018
other names :
polyadenylate-binding protein-interacting protein 2; Polyadenylate-binding protein-interacting protein 2; polyadenylate-binding protein-interacting protein 2; PABC1-interacting protein 2; PABP-interacting protein 2; polyA-binding protein-interacting protein 2; poly(A) binding protein interacting protein 2
products gene name :
PAIP2
other gene names :
PAIP2; PAIP2; PAIP-2; PAIP2A; PAIP2A; PABP-interacting protein 2; PAIP-2; Poly(A)-binding protein-interacting protein 2
uniprot entry name :
PAIP2_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP GVKYGNI.
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
The PAIP2 protein solution contains 20mM Tris-HCl, pH-8, 1mM DTT & 10% Glycerol. Sterile filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
products description :
Description: Recombinant Human PAIP2 produced in E Coli is a single,non-glycosylated polypeptide chain containing 147 amino acids (1-127 a.a.) and having a molecular mass of 17.1 kDa.PAIP2 human recombinant is fused to 20 amino acid His Tag at N-terminus and purified by convential chromatogrpahy techniques. Introduction: PAIP2 has a role as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. PAIP2 inhibitory activity on translation is mediated through its action on PABPC1. PAIP2 displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. PAIP2 association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
ncbi acc num :
NP_001028284.1
ncbi gb acc num :
NM_001033112.2
ncbi mol weight :
14,984 Da