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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Growth Arrest and DNA-Damage-Inducible Gamma
catalog :
MBS143759
quantity :
0.01 mg
price :
140 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143759
products type :
Recombinant Protein
products full name :
Recombinant Human Growth Arrest and DNA-Damage-Inducible Gamma
products short name :
Growth Arrest and DNA-Damage-Inducible Gamma
products name syn :
GADD45G Human; Growth Arrest and DNA-Damage-Inducible Gamma Human Recombinant; DDIT2; GADD45gamma; GADD45G; Growth arrest and DNA-damage-inducible protein GADD45 gamma; Cytokine-responsive protein CR6; DNA-damage-inducible transcript 2; DDIT-2; CR6; GRP17
other names :
growth arrest and DNA damage-inducible protein GADD45 gamma; Growth arrest and DNA damage-inducible protein GADD45 gamma; growth arrest and DNA damage-inducible protein GADD45 gamma; DDIT-2; DNA damage-inducible transcript 2 protein; GADD45-gamma; cytokine-responsive protein CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible, gamma; Cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein; DDIT-2
products gene name :
GADD45G
other gene names :
GADD45G; GADD45G; CR6; DDIT2; GRP17; GADD45gamma; CR6; DDIT2; DDIT-2
uniprot entry name :
GA45G_HUMAN
host :
E Coli
sequence length :
159
sequence :
MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL NVDPDNVTFC VLAAGEEDEG DIALQIHFTL IQAFCCENDIDIVRVGDVQR LAAIVGAGEE AGAPGDLHCI LISNPNEDAW KDPALEKLSL FCEESRSVND WVPSITLPE.
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
The GADD45G protein solution contains 20mM Tris-HCl pH-7. Sterile Filtered colorless solution.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; DNA-Damage Protein
products description :
Description: GADD45G Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 159 amino acids and having a molecular mass of 17.1 kDa. Introduction: GADD45G is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45G acts as a new-age tumor suppressor however is being frequently inactivated epigenetically in multiple tumors. GADD45G mRNA expression is down-regulated in hepatocellular carcinoma. GADD45G causes cell cycle arrest at G2/M transition when transfected into Hep-G2 cells. GADD45 Gamma induction by androgens involves new protein synthesis. Overexpression of GADD45 Gamma inhibits cell growth and causes morphological modifications in prostate cell lines thus GADD45 gamma takes part in differentiation induction by androgens.
ncbi gi num :
5729836
ncbi acc num :
NP_006696.1
ncbi gb acc num :
NM_006705.3
uniprot acc num :
O95257
ncbi mol weight :
17,121 Da
ncbi pathways :
Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!DNA Damage Response Pathway 198788!!FoxO Signaling Pathway 921162!!IL12-mediated Signaling Events Pathway 137922!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456!!P38 MAPK Signaling Pathway 137943!!P53 Signaling Pathway 83055!!P53 Signaling Pathway 465
ncbi summary :
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
size :
0.01 mg
price :
140 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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