protein

Recombinant Human Histidine NADH Dehydrogenase Fe-S Protein 4

MBS143739

1 mg

2665 USD

Recombinant Protein

Recombinant Human Histidine NADH Dehydrogenase Fe-S Protein 4

Histidine NADH Dehydrogenase Fe-S Protein 4

NDUFS4 Human; Histidine NADH Dehydrogenase Fe-S Protein 4 Human Recombinant; AQDQ; NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4 mitochondrial; NADH-ubiquinone oxidoreductase 18 kDa subunit; Complex I-18 kDa; CI-18 kDa; Complex I-AQDQ; CI-AQDQ

NADH dehydrogenase; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; CI-18 kDa; CI-AQDQ; NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit; complex I 18kDa subunit; complex I-18 kDa; complex I-AQDQ; mitochondrial respiratory chain complex I (18-KD subunit); NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); Complex I-18 kDa; CI-18 kDa; Complex I-AQDQ; CI-AQDQ; NADH-ubiquinone oxidoreductase 18 kDa subunit

NDUFS4

NDUFS4; NDUFS4; AQDQ; CI-18; CI-18 kDa; CI-AQDQ

NDUS4_HUMAN

E Coli

175

MAQDQTQDTQ LITVDEKLDI TTLTGVPEEH IKTRKVRIFV PARNNMQSGV NNTKKWKMEF DTRERWENPL MGWASTADPL SNMVLTFSTK EDAVSFAEKN GWSYDIEERK VPKPKSKSYG ANFSWNKRTR VSTK.

Greater than 90.0% as determined by SDS-PAGE.

The NDUFS4 solution contains 20mM Tris pH-8 & 30% glycerol. Sterile Filtered colorless solution.

NDUFS4 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

ENZYMES; Enzymes; Dehydrogenase

Description: NDUFS4 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 134 amino acids (43-175 a.a.) and having a molecular mass of 15.5 kDa.The NDUFS4 is purified by proprietary chromatographic techniques. Introduction: NDUFS4 is a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), the primary multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I is involved in cellular ATP production, the main source of energy for numerous vital processes in living cells. NDUFS4 removes electrons from NADH and passes them by a series of diverse protein-coupled redox centers to the electron acceptor ubiquinone. NDUFS4 presents a hotspot of mutations in the genetic apparatus of oxidative phosphorylation and the correct assembly of the subunit it encodes is essential for completion of the assembly of complex I.

4505369

NP_002486.1

NM_002495.2

O43181

20,108 Da

Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Electron Transport Chain Pathway 198860!!Huntington's Disease Pathway 83100!!Huntington's Disease Pathway 512!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway 413407!!NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway 890441!!Non-alcoholic Fatty Liver Disease (NAFLD) Pathway 862188

This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008]

1 mg

2665 USD