Recombinant Human Aldo-Keto Reductase Family 1 Member B10 | MyBioSource MBS143732 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Aldo-Keto Reductase Family 1 Member B10

catalog :

MBS143732

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143732

products type :

Recombinant Protein

products full name :

Recombinant Human Aldo-Keto Reductase Family 1 Member B10

products short name :

Aldo-Keto Reductase Family 1 Member B10

products name syn :

AKR1B10 Human; Aldo-Keto Reductase Family 1 Member B10 Human Recombinant; HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12; MGC14103; AKR1B10; Aldo-keto reductase family 1 member B10; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase

other names :

aldo-keto reductase family 1 member B10; Aldo-keto reductase family 1 member B10; aldo-keto reductase family 1 member B10; ARP; SI reductase; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like 1; aldose reductase-like peptide; aldose reductase-related protein; hARP; small intestine reductase; aldo-keto reductase family 1, member B10 (aldose reductase); ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase

products gene name :

AKR1B10

other gene names :

AKR1B10; AKR1B10; HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12; AKR1B11; ARP; hARP; SI reductase

uniprot entry name :

AK1BA_HUMAN

host :

E Coli

sequence length :

316

sequence :

MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVRKAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARIVENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFDAEY.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The AKR1B10 solution contains 20mM Tris-HCl pH-8 and 10% glycerol. Sterile Filtered clear colorless solution.

storage stability :

AKR1B10 Recombinant Human although stable at 4 degree C for 30 days, should be stored desiccated below -20 degree C for periods greater than 30 days. Please avoid freeze-thaw cycles.

products categories :

ENZYMES; Enzymes; Reductase

products description :

Description: AKR1B10 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 316 amino acids (1-316 a.a) and having a molecular mass of 36 kDa. The AKR1B10 is purified by proprietary chromatographic techniques. Introduction: AKR1B10 efficiently reduces aliphatic and aromatic aldehydes, and it is less active on hexoses. AKR1B10 is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. AKR1B10 is a monomeric protein that competently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is widely expressed in numerous human tissues, small intestine, colon and adrenal gland. AKR1B10 is pathogenically involved in diabetic complications and is overexpressed in human tumors, such as liver, breast, and lung cancer, AKR1B10 is involved in the development and progression of cancer.

ncbi gi num :

223468663

ncbi acc num :

NP_064695.3

ncbi gb acc num :

NM_020299.4

uniprot acc num :

O60218

ncbi mol weight :

36,020 Da

ncbi pathways :

Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Fructose And Mannose Metabolism Pathway (82930); Fructose And Mannose Metabolism Pathway (291); Galactose Metabolism Pathway (82931); Galactose Metabolism Pathway (292); Glycerolipid Metabolism Pathway (82986); Glycerolipid Metabolism Pathway (361); Metabolic Pathways (132956); Pentose And Glucuronate Interconversions Pathway (82929)

ncbi summary :

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

uniprot summary :

AKR1B10: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. Belongs to the aldo/keto reductase family. Protein type: Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.21; Carbohydrate Metabolism - butanoate; Oxidoreductase; Lipid Metabolism - linoleic acid; EC 1.1.1.-. Chromosomal Location of Human Ortholog: 7q33. Cellular Component: lysosome; cytosol. Molecular Function: protein binding; aldo-keto reductase activity; indanol dehydrogenase activity; geranylgeranyl reductase activity; retinal dehydrogenase activity. Biological Process: steroid metabolic process; phototransduction, visible light; digestion; aldehyde metabolic process; farnesol catabolic process; retinoid metabolic process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2920

more info or order :

MyBioSource product webpage