catalog number :
MBS143727
products type :
Recombinant Protein
products full name :
Recombinant Human Glycerol-3-Phosphate Dehydrogenase 1
products short name :
Glycerol-3-Phosphate Dehydrogenase 1
products name syn :
GPD1 Human; Glycerol-3-Phosphate Dehydrogenase 1 Human Recombinant; EC 1.1.1.8; Glycerol-3-phosphate dehydrogenase [NAD+]; GPDH-C; GPD-C; GPD1
other names :
glycerol-3-phosphate dehydrogenase; Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic; glycerophosphate dehydrogenase; glycerol-3-phosphate dehydrogenase 1 (soluble)
products gene name :
GPD1
other gene names :
GPD1; GPD1; GPD-C; HTGTI; GPDH-C; GPD-C; GPDH-C
uniprot entry name :
GPDA_HUMAN
sequence :
MASKKVCIVG SGNWGSAIAK IVGGNAAQLA QFDPRVTMWV FEEDIGGKKL TEIINTQHEN VKYLPGHKLP PNVVAVPDVV QAAEDADILI FVVPHQFIGK ICDQLKGHLK ANATGISLIK GVDEGPNGLK LISEVIGERL GIPMSVLMGA NIASEVADEK FCETTIGCKD PAQGQLLKEL MQTPNFRITV VQEVDTVEIC GALKNVVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGPVSSA TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE LLNGQKLQGP ETARELYSIL QHKGLVDKFP LFMAVYKVCY EGQPVGEFIH CLQNHPEHM.
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
The GPD1 protein solution contains 20mM Tris-HCl pH-8, and 10% glycerol. Sterile Filtered colorless solution.
products categories :
ENZYMES; Enzymes; Dehydrogenase
products description :
Description: GPD1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids (1-349 a.a.) and having a molecular mass of 37.5 kDa. The GPD1 is purified by conventional chromatography. Introduction: GPD1 enzyme catalyzes the reduction of dihydroxyacetone phosphate to sn-glycerol 3-phosphate. (sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH) previous names for glycerol-3-phosphate dehydrogenase include alpha glycerol-3-phosphate dehydrogenase and glycerolphosphate dehydrogenase. However, GPD1 differs from glyceraldehyde 3-phosphate dehydrogenase (GAPDH) whose substrate is an aldehyde not an alcohol.
ncbi acc num :
NP_001244128.1
ncbi gb acc num :
NM_001257199.1
ncbi mol weight :
35,140 Da
ncbi pathways :
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 160977!!Glycerophospholipid Biosynthesis Pathway 645313!!Glycerophospholipid Metabolism Pathway 82989!!Glycerophospholipid Metabolism Pathway 364!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Phospholipid Metabolism Pathway 645312!!Synthesis Of PA Pathway 645314!!Triacylglyceride Synthesis Pathway 198859!!Triglyceride Biosynthesis Pathway 106114
ncbi summary :
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]