Recombinant Human Glutaredoxin 3 | MyBioSource MBS143717 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Glutaredoxin 3

catalog :

MBS143717

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143717

products type :

Recombinant Protein

products full name :

Recombinant Human Glutaredoxin 3

products short name :

[Glutaredoxin 3]

products name syn :

[GLRX3 Human; Glutaredoxin-3 Human Recombinant; Glutaredoxin-3; Thioredoxin-like protein 2; PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; GLRX3; PICOT; TXNL2; GRX3; GRX4; GLRX4; TXNL3; FLJ11864; bA500G10.4]

other names :

[glutaredoxin-3; Glutaredoxin-3; glutaredoxin-3; PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; glutaredoxin 4; thioredoxin-like protein 2; glutaredoxin 3; PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2]

products gene name :

[GLRX3]

other gene names :

[GLRX3; GLRX3; GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3; PICOT; TXNL2; PICOT; PKCq-interacting protein]

uniprot entry name :

GLRX3_HUMAN

sequence length :

335

sequence :

MGSSHHHHHH SSGLVPRGSH MAAGAAEAAV AAVEEVGSAG QFEELLRLKA KSLLVVHFWA PWAPQCAQMN EVMAELAKEL PQVSFVKLEA EGVPEVSEKY EISSVPTFLF FKNSQKIDRL DGAHAPELTK KVQRHASSGS FLPSANEHLK EDLNLRLKKL THAAPCMLFM KGTPQEPRCG FSKQMVEILH KHNIQFSSFD IFSDEEVRQG LKAYSSWPTY PQLYVSGELI GGLDIIKELE ASEELDTICP KAPKLEERLK VLTNKASVML FMKGNKQEAK CGFSKQILEI LNSTGVEYET FDILEDEEVR QGLKAYSNWP TYPQLYVKGE LVGGLDIVKE LKENGELLPI LRGEN

purity :

Greater than 95% as determined by SDS-PAGE.

form :

0.5 mg/ml solution containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 1mM DTT

storage stability :

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

other info1 :

Source: E.coli

other info2 :

Physical Apprearance: Sterile filtered colorless solution

products categories :

ENZYMES; Enzymes; Gluteradoxin

products description :

Description: GLRX3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 355 amino acids (1-335 a.a.) and having a molecular mass of 39.6kDa. GLRX3 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: Glutaredoxin belongs to the thiol-disulfide oxidoreductase family. Glutraredoxins catalyze the reversible reduction of protein-glutathionyl mixed disulfides to free sulfhydryl groups though a monothiol mechanism. Glutaredoxin-3 (GRX3) is an important protein involved in the regulation of signal transduction, for example during immune cell activation and development of cardiac hypertrophy, apparently in response to redox signals. GRX3 interacts with PRKCQ. GRX3 may have a role in the regulation the function of the thioredoxin system. GRX3 is expressed in the heart, spleen, testis and, to a lower extent, in the thymus and peripheral blood leukocytes. GRX3 is weakly expressed in lung, placenta, colon and small intestine.

ncbi gi num :

315467838

ncbi acc num :

NP_001186797.1

ncbi gb acc num :

NM_001199868.1

uniprot acc num :

O76003

ncbi summary :

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

uniprot summary :

GLRX3: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. Protein type: Oxidoreductase. Chromosomal Location of Human Ortholog: 10q26. Cellular Component: cell cortex; Z disc. Molecular Function: protein binding; electron carrier activity; protein kinase C binding; metal ion binding; protein disulfide oxidoreductase activity; iron-sulfur cluster binding. Biological Process: cell redox homeostasis; regulation of the force of heart contraction

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2235

more info or order :

MyBioSource product webpage