protein

Recombinant Human D-Amino Acid Oxidase

MBS143713

0.01 mg

205 USD

Recombinant Protein

Recombinant Human D-Amino Acid Oxidase

D-Amino Acid Oxidase

DAAO Human; D-Amino Acid Oxidase Human Recombinant; D-amino-acid oxidase; DAMOX; DAAO; DAO; OXDA; MGC35381

D-amino-acid oxidase; D-amino-acid oxidase; D-amino-acid oxidase; D-amino acid oxidase; D-amino-acid oxidase

DAAO

DAO; DAO; DAAO; OXDA; DAMOX; DAMOX; DAAO; DAMOX; DAO

OXDA_HUMAN

E Coli

347

Greater than 95.0% as determined by SDS-PAGE.

The DAAO solution contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol and 1mM DTT. Sterile Filtered colorless solution.

ENZYMES; Enzymes; Oxidase

Description: DAAO Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 367 amino acids (1-347 a.a.) and having a molecular mass of 41.6kDa.The DAAO is purified by proprietary chromatographic techniques. Introduction: DAAO is a peroxisomal enzyme which uses FAD (flavin adenine dinucleotide) as a cofactor and oxidizes D-amino acids to the corresponding amino acids, producing ammonia and hydrogen peroxide. DAAO substrates include an extensive array of D-amino acids, but it is inactive on the naturally occurring L-amino acids. DAAO acts on a variety of D-amino acids especially on those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups; however it doesn't act on acidic amino acids. DAAO may be involved in acid base balance in the kidney or it could act as a detoxifying agent which removes D-amino acids accumulated during aging. DAAO regulates the neuromodulator D-serine level in the brain. DAAO is highly active towards D-DOPA and contributes to dopamine synthesis. Creatinine inhibits the DAAO in uremia. DAAO may also have a role in the pathophysiology of schizophrenia, but not in bipolar disorder.

148539837

NP_001908.3

NM_001917.4

P14920

39,474 Da

Arginine And Proline Metabolism Pathway 82957!!Arginine And Proline Metabolism Pathway 323!!D-Arginine And D-ornithine Metabolism Pathway 82972!!D-Arginine And D-ornithine Metabolism Pathway 341!!Glycine, Serine And Threonine Metabolism Pathway 82949!!Glycine, Serine And Threonine Metabolism Pathway 313!!Glyoxylate Metabolism Pathway 160990!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169

This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

0.01 mg

205 USD