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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Mothers Against Decapentaplegic Homolog 3
catalog :
MBS143711
quantity :
1 mg
price :
2220 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143711
products type :
Recombinant Protein
products full name :
Recombinant Human Mothers Against Decapentaplegic Homolog 3
products short name :
Mothers Against Decapentaplegic Homolog 3
products name syn :
SMAD3 Human; Mothers Against Decapentaplegic Homolog 3 Human Recombinant; MADH3; JV15-2; HSPC193; HsT17436; MGC60396; DKFZp586N0721; DKFZp686J10186; SMAD3; Mothers against decapentaplegic homolog 3; Mothers against DPP homolog 3; MAD homolog 3; Mad3; hMAD-3; SMAD family member 3; SMAD 3; hSMAD3
other names :
mothers against decapentaplegic homolog 3 isoform 2; Mothers against decapentaplegic homolog 3; mothers against decapentaplegic homolog 3; MAD homolog 3; MAD, mothers against decapentaplegic homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; hMAD-3; hSMAD3; mad homolog JV15-2; mad protein homolog; mad3; SMAD family member 3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3
products gene name :
SMAD3
other gene names :
SMAD3; SMAD3; LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; MADH3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; SMAD 3; Smad3; hSMAD3
uniprot entry name :
SMAD3_HUMAN
host :
E Coli
sequence length :
320
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
The SMAD3 protein solution contains 20mM Tris-HCl pH-8, 0.1M NaCl, 0.1mM DTT and 20% glycerol. Sterile Filtered colorless solution.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; SMAD
products description :
Description: SMAD3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 445 amino acids (1-425) and having a molecular mass of 50.2 kDa. SMAD3 is fused to a 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques. Introduction: SMAD3 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 has a role as a transcriptional modulator activated by TGF-Beta and is involved in the regulation of carcinogenesis. SMAD3 mutations are related with the pathogenesis of human osteoarthritis. SMAD3 expression take part in tumor suppression in the premature stages of gastric carcinogenesis. SMAD3 is involved in nuclear translocation of beta-catenin.
ncbi gi num :
223029440
ncbi acc num :
NP_001138574.1
ncbi gb acc num :
NM_001145102.1
uniprot acc num :
P84022
ncbi mol weight :
25,722 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!Activin Signaling Pathway 1084757!!Activin Signaling Pathway 1108220!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Adipogenesis Pathway 198832!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Androgen Receptor Signaling Pathway 198806!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054
ncbi summary :
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
size :
1 mg
price :
2220 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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