catalog number :
MBS143704
products type :
Recombinant Protein
products full name :
Recombinant Mouse Interleukin-2, His Tag
products short name :
Interleukin-2
products name syn :
IL 2 Mouse, His; Interleukin-2 Mouse Recombinant, His Tag; Interleukin-2; T-cell growth factor (TCGF); Aldesleukin; Lymphokine; IL-2; Il2; mIL 2 His
other names :
interleukin-2; Interleukin-2; interleukin-2; T-cell growth factor; TCGF; interleukin 2; T-cell growth factor; TCGF
products gene name :
mIL 2
other gene names :
Il2; Il2; Il-2; Il-2; IL-2; TCGF
uniprot entry name :
IL2_MOUSE
sequence :
MGSSHHHHHH SSGLVPRGSH MAPTSSSTSS STAEAQQQQQ QQQQQQQHLE QLLMDLQELL SRMENYRNLK LPRMLTFKFY LPKQATELKD LQCLEDELGP LRHVLDLTQS KSFQLEDAEN FISNIRVTVV KLKGSDNTFE CQFDDESATV VDFLRRWIAF CQSVISTSPQ.
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
The Mouse IL2 protein (0.5mg/ml) is supplied in Phosphate Buffered Saline (pH7.4) 0.1M NaCl, and 20% glycerol. Sterile Filtered colorless clear solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
other info2 :
Biological Activity: Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is < 2.5 ng/ml, corresponding to a specific activity of less than 400,000units/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
products description :
Description: Interleukin-2 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 170 amino acids (21-169 a.a) and having a molecular mass of 19.5kDa. The mouse IL-2 is fused to a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques. Introduction: IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
ncbi acc num :
NP_032392.1
ncbi gb acc num :
NM_008366.3
ncbi mol weight :
19,400 Da
ncbi pathways :
Allograft Rejection Pathway 83316!!Allograft Rejection Pathway 535!!Autoimmune Thyroid Disease Pathway 83314!!Autoimmune Thyroid Disease Pathway 533!!Chagas Disease (American Trypanosomiasis) Pathway 147810!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Cytokine Signaling In Immune System Pathway 1110778!!Cytokine-cytokine Receptor Interaction Pathway 83248!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response (BioCarta) Pathway 198283