protein

Recombinant Human Growth Arrest and DNA-Damage-Inducible Beta

MBS143695

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Growth Arrest and DNA-Damage-Inducible Beta

Growth Arrest and DNA-Damage-Inducible Beta

GADD45B Human; Growth Arrest and DNA-Damage-Inducible Beta Human Recombinant; MYD118; GADD45BETA; GADD45B; Growth arrest and DNA-damage-inducible protein GADD45 beta; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118; DKFZp566B133

growth arrest and DNA damage-inducible protein GADD45 beta; Growth arrest and DNA damage-inducible protein GADD45 beta; growth arrest and DNA damage-inducible protein GADD45 beta; myeloid differentiation primary response protein MyD118; negative growth regulatory protein MyD118; growth arrest and DNA-damage-inducible, beta; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118

GADD45B

GADD45B; GADD45B; MYD118; GADD45BETA; MYD118

GA45B_HUMAN

E Coli

160

MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIVRVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER.

Greater than 95.0% as determined by SDS-PAGE.

The GADD45B protein solution contains 20mM Tris-HCl pH-7.5 and 20% glycerol. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; DNA-Damage Protein

Description: GADD45B Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids and having a molecular mass of 17.8 kDa. Introduction: GADD45B is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45B reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45B is involved in the regulation of growth and apoptosis. GADD45b takes part during chondrocyte terminal differentiation and mediates MMP-13 gene expression. GADD45 in B cells is induced by CD40 via a mechanism that involves NF-kappa B and that induction suppresses Fas-mediated killing. GADD45b is down-regulated in most cases of hepatocellular carcinoma (HCC), and is a molecular marker in the diagnosis of HCC and as a possible therapeutic target.

86991436

NP_056490.2

NM_015675.3

O75293

17,818 Da

Adipogenesis Pathway 198832!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!DNA Damage Response Pathway 198788!!FoxO Signaling Pathway 921162!!IL12-mediated Signaling Events Pathway 137922!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456!!NF-kappa B Signaling Pathway 634527!!P38 MAPK Signaling Pathway 137943

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

0.01 mg

140 USD