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Recombinant Canine Apolipoprotein-J, HEK

MBS143693

0.01 mg

205 USD

MBS143693

Recombinant Protein

Recombinant Canine Apolipoprotein-J, HEK

Apolipoprotein-J

Clusterin Canine, HEK; Clusterin Canine Recombinant, HEK; CLI; AAG4; KUB1; SGP2; SGP-2; SP-40; TRPM2; MGC24903; Clusterin; Glycoprotein 80; Gp80; CLU; k9Clusterin HEK

clusterin; Clusterin; clusterin; clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J); glycoprotein 80; Glycoprotein 80; Gp80

CLU; CLU; GP80; Gp80

CLUS_CANFA

Human Embryonic Kidney 293 Cells

445

Greater than 95% as determined by SDS PAGE.

Canine Clusterin was filtered (0.4 um) and lyophilized from 0.5mg/ml solution containing 20mM Tris buffer and 20mM NaCl, pH 7.5. Filtered White lyophilized (freeze-dried) powder.

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Solubility: It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.

CYTOKINES AND GROWTH FACTORS; Cytokines; Apolipoprotein

Description: Clusterin Canine Recombinant produced in HEK293 cells is a glycosylated, Polypeptide chain containing 436 amino acids and having a molecular mass of 50.72 kDa. The protein is fused with 13 amino acid Flag tag at N-Terminus.The Apolipoprotein-J Canine is purified by proprietary chromatographic techniques. Introduction: Clusterin mRNA and Clusterin protein are shown to increase with androgen treatment. Binding of clusterin to the LDL-Receptor plays a role in the pathogenesis of membranous glomerulonephritis. Clusterin is down regulated in CaP in association with matched benign controls. Clusterin is involved in cellular senescence and tumorigenesis. Clusterin is involved in photo-oxidative cell death pathway. Clusterin is a functional tumor marker for the diagnosis of pediatric large cell lymphoma. Clusterin is activated in low pH. Clusterin is involved in the inhibition of NF-kappaB signaling through stabilization of IkappaBs thus results in suppression of tumor cell motility. N-terminal deletion of clusterin is vital for its alterations of biogenesis in esophageal squamous cell carcinoma.

50979240

NP_001003370.1

NM_001003370.1

P25473

51,790 Da

Hemostasis Pathway 1127909!!Platelet Activation, Signaling And Aggregation Pathway 1127919!!Platelet Degranulation Pathway 1127936!!Response To Elevated Platelet Cytosolic Ca2+ Pathway 1127934

This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]

0.01 mg

205 USD