catalog number :
MBS143692
products type :
Recombinant Protein
products full name :
Recombinant Human Epstein Barr Virus Induced 3, His Tag
products short name :
Epstein Barr Virus Induced 3
products name syn :
EBI3 Human, His; Epstein Barr Virus Induced 3 Human Recombinant, His Tag; Interleukin-27 subunit beta; IL-27 subunit beta; IL-27B; Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein; EBI3; IL27B; EBI3 His
other names :
interleukin-27 subunit beta; Interleukin-27 subunit beta; interleukin-27 subunit beta; EBV-induced gene 3 protein; Epstein-Barr virus induced gene 3; IL-27 subunit beta; IL27 subunit; IL35 subunit; cytokine receptor; epstein-Barr virus-induced gene 3 protein; Epstein-Barr virus induced 3; Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein
products gene name :
EBI3
other gene names :
EBI3; EBI3; IL27B; IL-27B; IL27B; IL-27 subunit beta; IL-27B; EBV-induced gene 3 protein
uniprot entry name :
IL27B_HUMAN
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
EBI3 protein is supplied in 1xPBS, 50% glycerol. Sterile Filtered clear solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; EBI3
products description :
Description: EBI3 Human Recombinant produced in E Coli is a single, non-glycosylated, Polypeptide chain containing 209 amino acids fragment (21-229) having a molecular weight of 34kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The EBI3 is purified by proprietary chromatographic techniques. Introduction: EBI3 has an induced expression in B lymphocytes in reaction to Epstein-Barr virus infection. EBI3 encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form iIL-27. EBI3 drives rapid clonal expansion of naive cd4(+) t-cells. EBI3 strongly synergizes with IL-12 to activate IFN-gamma production of naive cd4(+) t-cells. EBI3 mediates its biologic effects through the cytokine receptor wsx-1/tccr.
ncbi acc num :
NP_005746.2
ncbi gb acc num :
NM_005755.2
ncbi mol weight :
25,396 Da
ncbi pathways :
IL27-mediated Signaling Events Pathway 137929
ncbi summary :
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]