product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Ketohexokinase
catalog :
MBS143682
quantity :
1 mg
price :
2220 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS143682
products type :
Recombinant Protein
products full name :
Recombinant Human Ketohexokinase
products short name :
Ketohexokinase
products name syn :
Ketohexokinase Human; Ketohexokinase Human Recombinant; KHK; Hepatic Fructokinase; Ketohexokinase; Fructokinase; Ketohexokinase
other names :
ketohexokinase isoform a; Ketohexokinase; ketohexokinase; hepatic fructokinase; ketohexokinase (fructokinase); Hepatic fructokinase
other gene names :
KHK; KHK
uniprot entry name :
KHK_HUMAN
host :
E Coli
sequence length :
298
sequence :
MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV.
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
The protein solution contains 1xPBS, pH 7.4 and 10% glycerol. Sterile filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
products categories :
PROTEIN KINASES; Enzymes; Protein Kinases
products description :
Description: Ketohexokinase Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids and having a molecular mass of 32.7 kDa. Introduction: Ketohexokinase catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, resulting in the utilization of ATP and creation of AMP. Ketohexokinase commences initial step in the metabolism of dietary fructose and is a significant regulator of hepatic glucose metabolism. Ketohexokinase is found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. ketohexokinase plays an unknown physiologic function that remains intact in essential fructosuria. Ketohexokinase expression is reduceed in human clear cell type of renal cell carcinoma.
ncbi gi num :
4557693
ncbi acc num :
NP_000212.1
ncbi gb acc num :
NM_000221.2
uniprot acc num :
P50053
ncbi mol weight :
32,523 Da
ncbi pathways :
Disease Pathway 530764!!Fructose And Mannose Metabolism Pathway 82930!!Fructose And Mannose Metabolism Pathway 291!!Fructose Catabolism Pathway 106218!!Glycogen Storage Diseases Pathway 1127581!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Carbohydrates Pathway 106196!!Myoclonic Epilepsy Of Lafora Pathway 1127582!!Polyol Pathway 198815
ncbi summary :
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
size :
1 mg
price :
2220 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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