Recombinant Human Growth and Differentiation factor 15, His Tag | MyBioSource MBS143675 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Growth and Differentiation factor 15, His Tag

catalog :

MBS143675

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143675

products type :

Recombinant Protein

products full name :

Recombinant Human Growth and Differentiation factor 15, His Tag

products short name :

Growth and Differentiation factor 15

products name syn :

GDF15 Human, His; Growth and Differentiation Factor 15 Human Recombinant, His Tag; GDF-15; MIC1; MIC-1; NAG-1; PDF; PLAB; PTGFB; Growth/differentiation factor 15; Placental bone morphogenetic protein; Placental TGF-beta; Macrophage inhibitory cytokine 1; Prostate differentiation factor; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; NRG-1; GDF15; GDF15 His

other names :

growth/differentiation factor 15; Growth/differentiation factor 15; growth/differentiation factor 15; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PTGF-beta; macrophage inhibitory cytokine 1; placental TGF-beta; placental bone morphogenetic protein; prostate differentiation factor; growth differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor

products gene name :

GDF15

other gene names :

GDF15; GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; MIC1; PDF; PLAB; PTGFB; GDF-15; MIC-1; NAG-1; NRG-1

uniprot entry name :

GDF15_HUMAN

host :

E Coli

sequence length :

308

sequence :

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The GDF15 protein solution contains 10mM sodium citrate, pH-3.5 & 10% glycerol. Sterile filtered colorless solution.

concentration :

0.5 mg/ml

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Bone Morphogenetic Protein

products description :

Description: Recombinant Human GDF15 produced in E Coli is a single, non-glycosylated polypeptide chain containing 151 amino acids (195-308) and having a molecular mass of 16.7 kDa(molecular weight on SDS-PAGE will appear higher).GDF15 is expressed with a 36 amino acid His tag fused at N-Terminus and purified by proprietary chromatographic techniques. Introduction: GDF15 is part of the TGF-Beta superfamily that is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance.

ncbi gi num :

153792495

ncbi acc num :

NP_004855.2

ncbi gb acc num :

NM_004864.2

uniprot acc num :

Q99988

ncbi mol weight :

34,140 Da

ncbi pathways :

Direct P53 Effectors Pathway (137939)

ncbi summary :

Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]

uniprot summary :

GDF15: disulfide-linked. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Cytokine; Secreted. Chromosomal Location of Human Ortholog: 19p13.11. Cellular Component: extracellular space; extracellular region. Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: regulation of apoptosis; cell-cell signaling; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; signal transduction; cell development

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage