Recombinant Human Aldo-Keto Reductase Family 1 Member A1 | MyBioSource MBS143662 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Aldo-Keto Reductase Family 1 Member A1

catalog :

MBS143662

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143662

products type :

Recombinant Protein

products full name :

Recombinant Human Aldo-Keto Reductase Family 1 Member A1

products short name :

Aldo-Keto Reductase Family 1 Member A1

products name syn :

AKR1A1 Human; Aldo-Keto Reductase Family 1 Member A1 Human Recombinant; Alcohol dehydrogenase; ALR; ARM; DD3; ALDR1; MGC1380; MGC12529; AKR1A1; Alcohol dehydrogenase [NADP+]; Aldehyde reductase; Aldo-keto reductase family 1 member A1

other names :

alcohol dehydrogenase; Alcohol dehydrogenase [NADP(+)]; alcohol dehydrogenase [NADP(+)]; alcohol dehydrogenase [NADP(+)]; HEL-S-165mP; aldehyde reductase; aldo-keto reductase family 1 member A1; dihydrodiol dehydrogenase 3; epididymis secretory protein Li 6; epididymis secretory sperm binding protein Li 165mP; aldo-keto reductase family 1, member A1 (aldehyde reductase); Aldehyde reductase; Aldo-keto reductase family 1 member A1

products gene name :

AKR1A1

other gene names :

AKR1A1; AKR1A1; ALR; ARM; DD3; ALDR1; HEL-S-6; ALDR1; ALR

uniprot entry name :

AK1A1_HUMAN

host :

E Coli

sequence length :

325

sequence :

MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE PVVLALAEKY GRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY.

purity :

Greater than 90% as determined by SDS-PAGE.

form :

AKR1A1 solution containing 20mM Tris pH-8, 50mM NaCl and 10% glycerol. Sterile filtered colorless solution.

concentration :

1mg/ml

storage stability :

AKR1A1 Human Recombinant although stable at 4 degree C for 1 week, should be stored below -18 degree C. Please prevent freeze thaw cycles.

products categories :

ENZYMES; Enzymes; Reductase

products description :

Description: AKR1A1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 325 amino acids (1-325 a.a.) and having a molecular mass of 36.5 kDa. AKR1A1 is purified by proprietary chromatographic techniques. Introduction: AKR1A1 is part of the aldo/keto reductase superfamily, it catalyzes the NADPH-dependent reduction from a range of aromatic and aliphatic aldehydes to their related alcohols. AKR1A1 corresponds (65% identity) to aldose reductase, an enzyme that takes part in the pathogenesis of some diabetic and galactosemic complications. AKR1A1 is involved in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin and daunorubicin.

ncbi gi num :

320202988

ncbi acc num :

NP_001189342.1

ncbi gb acc num :

NM_001202413.1

uniprot acc num :

P14550

ncbi mol weight :

36,573 Da

ncbi pathways :

Benzo(a)pyrene Metabolism Pathway (198911); Degradation Of Aromatic Compounds Pathway (843021); Degradation Of Aromatic Compounds Pathway (717401); Glucuronate Pathway (uronate Pathway) (997799); Glucuronate Pathway (uronate Pathway) (468207); Glycerolipid Metabolism Pathway (82986); Glycerolipid Metabolism Pathway (361); Glycolysis / Gluconeogenesis Pathway (82926); Glycolysis / Gluconeogenesis Pathway (287); Metabolic Pathways (132956)

ncbi summary :

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

uniprot summary :

AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family. Protein type: Lipid Metabolism - glycerolipid; EC 1.1.1.2; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Oxidoreductase. Chromosomal Location of Human Ortholog: 1p33-p32. Cellular Component: extracellular space; apical plasma membrane; cytosol. Molecular Function: L-glucuronate reductase activity; electron carrier activity; aldehyde reductase activity. Biological Process: aldehyde catabolic process; L-ascorbic acid biosynthetic process; D-glucuronate catabolic process; glucose metabolic process; aldehyde metabolic process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2220

more info or order :

MyBioSource product webpage