protein

Recombinant Human Apolipoprotein A-I, His Tag

MBS143660

0.02 mg

140 USD

Recombinant Protein

Recombinant Human Apolipoprotein A-I, His Tag

Apolipoprotein A-I

APOA1 Human, His; Apolipoprotein A-I Human Recombinant, His Tag; Apolipoprotein A-I; Apo-AI; ApoA-I; APOA1; MGC117399; APOA1, His

apolipoprotein A-I preproprotein; Apolipoprotein A-I; apolipoprotein A-I; apo-AI; apolipoprotein A-I; Apolipoprotein A1Cleaved into the following 2 chains:Proapolipoprotein A-I; ProapoA-I; Truncated apolipoprotein A-IAlternative name(s):Apolipoprotein A-I(1-242)

APOA1

APOA1; APOA1; Apo-AI; ApoA-I; ProapoA-I

APOA1_HUMAN

E Coli

267

Greater than 95.0% as determined by SDS-PAGE.

The APOA1 solution containing 20mM Tris-HCl buffer (pH8.0) and 10% glycerol. Sterile filtered colorless solution.

CYTOKINES AND GROWTH FACTORS; Cytokines; Apolipoprotein

Description: APOA1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 264 amino acids (25-267 a.a.) and having a molecular mass of 30.3kDa. APOA1 is fused to 20 a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: APOA1 (Apolipoprotein A-1) is a human protein with a specific role in lipid metabolism being the main protein component of HDL in the plasma. APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Furthermore, APOA1 is a cofactor for LCAT, which is responsible for the formation of most plasma cholesteryl esters. In addition, APOA1 activates spermatozoa motility as part of the SPAP complex. The APOA1 gene is strongly linked with two other apolipoprotein genes on chromosome 11. Defects in the APOA1 gene are linked to HDL deficiency including Tangier disease, and with systemic non-neuropathic amyloidosis. High levels of APOA1 are linked to the manifestation of asthma and atopy.

4557321

NP_000030.1

NM_000039.1

P02647

30,778 Da

ABC-family Proteins Mediated Transport Pathway 106573!!ABCA Transporters In Lipid Homeostasis Pathway 477112!!African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Amyloids Pathway 366238!!Binding And Uptake Of Ligands By Scavenger Receptors Pathway 771599!!Chylomicron-mediated Lipid Transport Pathway 106157!!Disease Pathway 530764!!Diseases Associated With Visual Transduction Pathway 771581!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]

0.02 mg

140 USD