Recombinant Human Glutathione S-Transferase Alpha 1 | MyBioSource MBS143651 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Glutathione S-Transferase Alpha 1

catalog :

MBS143651

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143651

products type :

Recombinant Protein

products full name :

Recombinant Human Glutathione S-Transferase Alpha 1

products short name :

Glutathione S-Transferase Alpha 1

products name syn :

GSTA1 Human; Glutathione S-Transferase Alpha-1 Human Recombinant; GST2; GSTA1-1; GTH1; GSTA-1; GSTAI; GSTA-I; EC 2.5.1.18; Glutathione S-transferase A1; GST HA subunit 1; GST-epsilon; GST class-alpha member 1; GSTA1; MGC131939

other names :

glutathione S-transferase A1; Glutathione S-transferase A1; glutathione S-transferase A1; GST HA subunit 1; GST class-alpha member 1; GST, class alpha, 1; GST-epsilon; S-(hydroxyalkyl)glutathione lyase A1; glutathione S-alkyltransferase A1; glutathione S-aryltransferase A1; glutathione S-transferase 2; glutathione S-transferase Ha subunit 1; glutathione S-transferase alpha 1; GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1Glutathione S-transferase A1, N-terminally processed

products gene name :

GSTA1

other gene names :

GSTA1; GSTA1; GST2; GTH1; GSTA1-1

uniprot entry name :

GSTA1_HUMAN

host :

E Coli

sequence length :

222

sequence :

MAEKPKLHYF NARGRMESTR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYIEGIA DLGEMILLLP VCPPEEKDAK LALIKEKIKN RYFPAFEKVL KSHGQDYLVG NKLSRADIHL VELLYYVEEL DSSLISSFPL LKALKTRISN LPTVKKFLQP GSPRKPPMDE KSLEEARKIF RF.

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

The GSTA1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol. Sterile Filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

other info2 :

Biological Activity: Specific activity is 5-8 units/mg, and is defined as the amount of enzyme that conjugate 1.0 u mole of 1-chloro-2,4-dinitrobenzene (CDNB) with reduced glutathione per minute at pH 6.5 at 25 degree C.

products categories :

ENZYMES; Enzymes; Transferase

products description :

Description: GSTA1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 222 amino acids (1-222 a.a.) and having a molecular mass of 25.6 kDa. The GSTA1 is purified by proprietary chromatographic techniques. Introduction: Membrane-bound & Cytosolic forms of GST are encoded by 2 separate supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. There are 8 different classes of soluble cytoplasmic mammalian GST: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTA1 is found in a cluster mapped to chromosome 6, and is highly expressed in the liver. GSTA1 protects the cells from reactive oxygen species.

ncbi gi num :

22091454

ncbi acc num :

NP_665683.1

ncbi gb acc num :

NM_145740.3

uniprot acc num :

P08263

ncbi mol weight :

25,631 Da

ncbi pathways :

4-hydroxy-2-nonenal Detoxification Pathway (703096); 4-hydroxy-2-nonenal Detoxification Pathway (703144); AhR Pathway (755436); Biological Oxidations Pathway (105698); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway (1127639); Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway (1127658); Defective GGT1 Causes Glutathionuria (GLUTH) Pathway (1127659); Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway (1127660)

ncbi summary :

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]

uniprot summary :

GSTA1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Alpha family. Protein type: Other Amino Acids Metabolism - glutathione; EC 2.5.1.18; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450. Chromosomal Location of Human Ortholog: 6p12.1. Cellular Component: cytosol. Molecular Function: glutathione transferase activity. Biological Process: glutathione metabolic process; epithelial cell differentiation; metabolic process; xenobiotic metabolic process

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

205

size3 :

1 mg

price3 :

2220

more info or order :

MyBioSource product webpage