Recombinant Human Estrogen Sulfotransferase | MyBioSource MBS143649 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Estrogen Sulfotransferase

catalog :

MBS143649

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143649

products type :

Recombinant Protein

products full name :

Recombinant Human Estrogen Sulfotransferase

products short name :

Estrogen Sulfotransferase

products name syn :

SULT1E1 Human; Estrogen Sulfotransferase Human Recombinant; EST; STE; EST-1; MGC34459; SULT1E1; Estrogen sulfotransferase; Sulfotransferase estrogen-preferring

other names :

estrogen sulfotransferase; Estrogen sulfotransferase; estrogen sulfotransferase; estrone sulfotransferase; sulfotransferase 1E1; sulfotransferase, estrogen-preferring; sulfotransferase family 1E, estrogen-preferring, member 1; EST-1; Sulfotransferase 1E1; ST1E1; Sulfotransferase, estrogen-preferring

products gene name :

SULT1E1

other gene names :

SULT1E1; SULT1E1; EST; STE; EST-1; ST1E1; STE; ST1E1

uniprot entry name :

ST1E1_HUMAN

host :

E Coli

sequence length :

294

sequence :

MNSELDYYEK FEEVHGILMY KDFVKYWDNV EAFQARPDDL VIATYPKSGT TWVSEIVYMI YKEGDVEKCK EDVIFNRIPF LECRKENLMN GVKQLDEMNS PRIVKTHLPP ELLPASFWEK DCKIIYLCRN AKDVAVSFYY FFLMVAGHPN PGSLPEFVEK FMQGQVPYGS WYKHVKSWWE KGKSPRVLFL FYEDLKEDIR KEVIKLIHFL ERKPSEELVD RIIHHTSFQE MKNNPSTNYT TLPDEIMNQK LSPFMRKGIT GDWKNHFTVA LNEKFDKHYE QQMKESTLKF RTEILEHHHH HH.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The SULT1E1 protein solution contains 20mM Tris-HCl, pH-8 and 20% Glycerol. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

ENZYMES; Enzymes; Transferase

products description :

Description: Recombinant Human SULT1E1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 302 amino acids (1-294 a.a.) and having a molecular mass of 36.1 kDa. SULT1E1 is fused to 6 amino acid His Tag at C-terminus and purified by conventional chromatography techniques. Introduction: SULT1E1 catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULTIE1 control the level of the estrogen receptor by sulfurylating free estradiol. maximally sulfates beta-estradiol and estrone at concentrations of 20nm. SULTIE1 in addition sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at considerably higher concentrations; though, cortisol, testosterone and dopamine are not sulfated. Decreased SULT1E1 expression is linked with estrogen-dependent endometrial carcinomas. Altered cellular proliferation was detected in cells stably expressing SULT1E1.

ncbi gi num :

4885617

ncbi acc num :

NP_005411.1

ncbi gb acc num :

NM_005420.2

uniprot acc num :

P49888

ncbi mol weight :

35,126 Da

ncbi pathways :

Biological Oxidations Pathway (105698); Cytosolic Sulfonation Of Small Molecules Pathway (105724); Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway (1127639); Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway (1127658); Defective GGT1 Causes Glutathionuria (GLUTH) Pathway (1127659); Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway (1127660); Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway (1127663); Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway (1127661); Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway (1127665); Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway (1127666)

ncbi summary :

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

uniprot summary :

SULT1E1: Sulfotransferase that utilizes 3 -phospho-5 -adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated. Belongs to the sulfotransferase 1 family. Protein type: Transferase; EC 2.8.2.4; Lipid Metabolism - androgen and estrogen; Energy Metabolism - sulfur. Chromosomal Location of Human Ortholog: 4q13.1. Cellular Component: cytosol. Molecular Function: steroid sulfotransferase activity; estrone sulfotransferase activity; flavonol 3-sulfotransferase activity; steroid binding. Biological Process: steroid metabolic process; estrogen metabolic process; xenobiotic metabolic process; sulfation; female pregnancy; 3 -phosphoadenosine 5 -phosphosulfate metabolic process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage