Recombinant Human Peroxiredoxin-2 | MyBioSource MBS143638 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Peroxiredoxin-2

catalog :

MBS143638

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143638

products type :

Recombinant Protein

products full name :

Recombinant Human Peroxiredoxin-2

products short name :

Peroxiredoxin-2

products name syn :

PRDX2 Human; Peroxiredoxin-2 Human Recombinant; PRP; TSA; PRX2; NKEFB; PRXII; TDPX1; MGC4104; PRDX2; Peroxiredoxin-2; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thiol-specific antioxidant protein; Natural killer cell-enhancing factor B; NKEF-B

other names :

peroxiredoxin-2; Peroxiredoxin-2; peroxiredoxin-2; epididymis secretory sperm binding protein Li 2a; natural killer cell-enhancing factor B; thiol-specific antioxidant 1; thioredoxin peroxidase 1; thioredoxin-dependent peroxide reductase 1; torin; peroxiredoxin 2; Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1

products gene name :

PRDX2

other gene names :

PRDX2; PRDX2; PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a; NKEFB; TDPX1; NKEF-B; TSA

uniprot entry name :

PRDX2_HUMAN

host :

E Coli

sequence length :

198

sequence :

MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS DTIKPNVDDS KEYFSKHN.

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

The Peroxiredoxin solution contains 20mM Tris-HCl pH-8, & 10% glycerol. Sterile Filtered colorless solution.

storage stability :

PRDX2 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

other info2 :

Biological Activity: The specific activity was found to be approximately 200-230 pmole/min/ ug. The enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX2 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25 degree C for 1 minute.

products categories :

ENZYMES; Enzymes; Peroxiredoxin

products description :

Description: PRDX2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 198 amino acids and having a molecular mass of 21.8 kDa.The PRDX2 is purified by proprietary chromatographic techniques. Introduction: PRDX2 is part of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. PRDX2 takes part as an antioxidant protective role in cells, and contributes to the antiviral activity of CD8(+) T-cells. PRDX2 has proliferative effect in cancer development or progression. If PRDX2 protection is insufficient against peroxidases, the DNA damage results in neurological disease such as Alzheimer's or DNA damage leading to cancer.

ncbi gi num :

32189392

ncbi acc num :

NP_005800.3

ncbi gb acc num :

NM_005809.5

uniprot acc num :

P32119

ncbi mol weight :

15,819 Da

ncbi pathways :

Cellular Responses To Stress Pathway (645258); Detoxification Of Reactive Oxygen Species Pathway (1127552); Selenium Pathway (198825)

ncbi summary :

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

uniprot summary :

PRDX2: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Three splice-variant isoforms have been identified. Protein type: Oxidoreductase; EC 1.11.1.15. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: cytoplasm; cytosol. Molecular Function: antioxidant activity; thioredoxin peroxidase activity. Biological Process: regulation of apoptosis; response to reactive oxygen species; removal of superoxide radicals; hydrogen peroxide catabolic process; response to oxidative stress; negative regulation of neuron apoptosis; negative regulation of apoptosis

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2920

more info or order :

MyBioSource product webpage