Recombinant Human Serum Amyloid A (APO-SAA1), His Tag | MyBioSource MBS143634 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Serum Amyloid A (APO-SAA1), His Tag

catalog :

MBS143634

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143634

products type :

Recombinant Protein

products full name :

Recombinant Human Serum Amyloid A (APO-SAA1), His Tag

products short name :

Serum Amyloid A

products name syn :

SAA1 Human, His; Serum Amyloid A Human Recombinant (APO-SAA1), His Tag; Serum amyloid A protein; SAA; Amyloid protein A; Amyloid fibril protein AA; SAA1; SAA2; PIG4; TP53I4; MGC111216; SAA1 His

other names :

serum amyloid A-1 protein preproprotein; Serum amyloid A-1 protein; serum amyloid A-1 protein; serum amyloid A protein; tumor protein p53 inducible protein 4; serum amyloid A1; Amyloid fibril protein AA

products gene name :

SAA1

other gene names :

SAA1; SAA1; SAA; PIG4; SAA2; TP53I4; SAA

uniprot entry name :

SAA1_HUMAN

host :

E Coli

sequence length :

122

sequence :

MGSSHHHHHH SSGLVPRGSH MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGP GGVWAAEAIS DARENIQRFF GHGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The SAA1 Solution (1mg/ml) contains 20mM Tris buffer (pH8.0) and 10% glycerol. Sterile Filtered colorless solution.

concentration :

1mg/ml

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Serum Amyloid A

products description :

Description: SAA1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 125 amino acids (19-122 a.a.) and having a total molecular mass of 13.9 kDa. SAA1 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: SAA1 protein is an acute phase apolipoprotein reactant which is produced mostly by hepatocytes and under regulation of inflammatory cytokines. SAA1 (Serum amyloid A1) protein is produced mainly in the liver and circulates in low levels in the blood. The SAA1 seems to have a role in the immune system. SAA1 protein levels increase in the blood and other tissues under conditions of inflammation. SAA1 may facilitate the repair of injured tissues; it also acts as an antibacterial agent, and signals the migration of germ-fighting cells to sites of infection. SAA1 also functions as an apolipoprotein of the HDL complex.Elevated levels of SAA1 ultimately affect secondary amyloidosis, extracellular amassing of amyloid fibrils, resulting from a circulating precursor, in a variety of tissues and organs. The most widespread type of amyloidosis appears secondary to chronic inflammatory disease, mainly rheumatoid arthritis. The SAA1 cleavage product a designated amyloid protein A is deposited systemically as amyloid in vital organs such as the liver, spleen, and kidneys in chronic inflammatory diseases patients. These deposits are extremely insoluble and resistant to proteolysis; they disrupt tissue structure and compromise performance.

ncbi gi num :

40316912

ncbi acc num :

NP_000322.2

ncbi gb acc num :

NM_000331.4

uniprot acc num :

P0DJI8

ncbi mol weight :

13,532 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Advanced Glycosylation Endproduct Receptor Signaling Pathway (187092); Amyloids Pathway (366238); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway (833822); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); Folate Metabolism Pathway (198833)

ncbi summary :

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]

uniprot summary :

SAA1: Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11p15.1. Cellular Component: extracellular region. Molecular Function: heparin binding; G-protein-coupled receptor binding. Biological Process: receptor-mediated endocytosis; platelet activation; neutrophil chemotaxis; positive regulation of cell adhesion; macrophage chemotaxis; positive regulation of interleukin-1 secretion; elevation of cytosolic calcium ion concentration; regulation of protein secretion; negative regulation of inflammatory response; acute-phase response; innate immune response; lymphocyte chemotaxis; positive regulation of cytokine secretion

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

205

size3 :

1 mg

price3 :

1705

more info or order :

MyBioSource product webpage