protein

Recombinant Human Mothers Against Decapentaplegic Homolog 4

MBS143633

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Mothers Against Decapentaplegic Homolog 4

Mothers Against Decapentaplegic Homolog 4

SMAD4 Human; Mothers Against Decapentaplegic Homolog 4 Human Recombinant; JIP; DPC4; MADH4; SMAD-4; DPC-4; MADH-4; Mothers against decapentaplegic homolog 4; Mothers against DPP homolog 4; SMAD 4; hSMAD4; Deletion target in pancreatic carcinoma 4; SMAD4; SMAD family member 4

mothers against decapentaplegic homolog 4; Mothers against decapentaplegic homolog 4; mothers against decapentaplegic homolog 4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; SMAD family member 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4

SMAD4

SMAD4; SMAD4; JIP; DPC4; MADH4; MYHRS; DPC4; MADH4; MAD homolog 4; Mothers against DPP homolog 4; SMAD 4; Smad4; hSMAD4

SMAD4_HUMAN

E Coli

552

Greater than 90.0% as determined by SDS-PAGE.

The SMAD4 protein solution contains 20mM Tris-HCl pH-8, and 20% glycerol. Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; SMAD

Description: SMAD4 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 572 amino acids (1-552) and having a molecular mass of 62.6 kDa. SMAD4 is fused to a 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques. Introduction: SMAD4 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD4 promotes the binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides the function of activation required for SMAD1 or SMAD2 to stimulate transcription acts as a tumor suppressor. SMAD4 is a target molecule for functional inactivation in cervical cancer. SMAD4 is an important biomarker for malignant transformation atakes part in inducing apoptosis by modulating Bcl-2/Bax balance.

4885457

NP_005350.1

NM_005359.5

Q13485

60,439 Da

ALK1 Signaling Events Pathway 137968!!ALK2 Signaling Events Pathway 137983!!Activin Signaling Pathway 1084757!!Activin Signaling Pathway 1108220!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Androgen Receptor Signaling Pathway 198806!!BMP Signalling Pathway 545370!!BMP Receptor Signaling Pathway 137948!!BMP Signaling Pathway 1084755

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]

0.01 mg

140 USD