protein

Recombinant Mouse Glutathione S-Transferase M1

MBS143631

0.01 mg

140 USD

Recombinant Protein

Recombinant Mouse Glutathione S-Transferase M1

Glutathione S-Transferase M1

GSTM1 Mouse; Glutathione S-Transferase M1 Mouse Recombinant; GST1; GTH4; GTM1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b; GSTM1; Glutathione S-transferase Mu 1; GST class-mu 1; Glutathione S-transferase GT8.7; pmGT10; GST 1-1

glutathione S-transferase Mu 1; Glutathione S-transferase Mu 1; glutathione S-transferase Mu 1; GST 1-1; GST class-mu 1; glutathione S-transferase GT8.7; glutathione-S-transferase, mu 1; pmGT10; glutathione S-transferase, mu 1; GST 1-1; GST class-mu 1; Glutathione S-transferase GT8.7; pmGT10

mGSTM1

Gstm1; Gstm1; Gstb1; Gstb-1

GSTM1_MOUSE

E Coli

218

MPMILGYWNV RGLTHPIRML LEYTDSSYDE KRYTMGDAPD FDRSQWLNEK FKLGLDFPNL PYLIDGSHKI TQSNAILRYL ARKHHLDGET EEERIRADIV ENQVMDTRMQ LIMLCYNPDF EKQKPEFLKT IPEKMKLYSE FLGKRPWFAG DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS SRYIATPIFS KMAHWSNK.

Greater than 95.0% as determined by SDS-PAGE.

The GSTM1 solution contains PBS pH-7.4 & 5mM glutathione. Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Biological Activity: Specific activity is 3 units/mg, and is defined as the amount of enzyme that conjugate 1.0 u mole of 1-chloro-2,4-dinitrobenzene (CDNB) with reduced glutathione per minute at pH 6.5 at 25 degree C.

ENZYMES; Enzymes; Transferase

Description: GSTM1 Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 218 amino acids and having a molecular mass of 25.9 kDa.The GTM1 is purified by proprietary chromatographic techniques. Introduction: Cytosolic and membrane-bound types of GST are encoded by 2 different supergene families. There are 8 classes of the soluble cytoplasmic mammalian GST: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are arranged in a gene cluster on chromosome 1p13.3 and aare highly polymorphic. These genetic differences can change an individual's resistance to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with the rise in a number of cancers.

6754084

NP_034488.1

NM_010358.5

P10649

25,970 Da

Aflatoxin B1 Metabolism Pathway 198417!!Biological Oxidations Pathway 1111015!!Chemical Carcinogenesis Pathway 673229!!Chemical Carcinogenesis Pathway 673237!!Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway 1111461!!Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway 1111480!!Defective GGT1 Causes Glutathionuria (GLUTH) Pathway 1111481!!Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway 1111482!!Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway 1111485!!Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway 1111483

0.01 mg

140 USD