Recombinant Human GABA(A) Receptor-Associated Protein | MyBioSource MBS143630 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human GABA(A) Receptor-Associated Protein

catalog :

MBS143630

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143630

products type :

Recombinant Protein

products full name :

Recombinant Human GABA(A) Receptor-Associated Protein

products short name :

GABA(A) Receptor-Associated Protein

products name syn :

GABARAP Human; GABA(A) Receptor-Associated Protein Human Recombinant; GBRAP; MM46; GABA(A) receptor-associated protein; Gamma-aminobutyric acid receptor-associated protein; GABARAP; FLJ25768; MGC120154; MGC120155; FLC3B

other names :

gamma-aminobutyric acid receptor-associated protein; Gamma-aminobutyric acid receptor-associated protein; gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; GABA(A) receptor-associated protein; MM46

products gene name :

GABARAP

other gene names :

GABARAP; GABARAP; MM46; ATG8A; GABARAP-a; FLC3B

uniprot entry name :

GBRAP_HUMAN

host :

E Coli

sequence length :

117

purity :

Greater than 95% as determined by SDS-PAGE.

form :

GABARAP solution (1mg/ml) containing 20mM Tris-HCl pH-8, 0.2M NaCl and 20% glycerol. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; GABA(A) Receptor-Associated Protein

products description :

Description: GABARAP Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 137 amino acids (1-117 a.a.) and having a molecular mass of 16 kDa. GABARAP is fused to a 20 amino acid His-Tag at N-Terminus and purified by proprietary chromatographic techniques. Introduction: GABARAP is a ligand-gated chloride channel that mediates inhibitory neurotransmission. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.

ncbi gi num :

6005764

ncbi acc num :

NP_009209.1

ncbi gb acc num :

NM_007278.1

uniprot acc num :

O95166

ncbi mol weight :

13,918 Da

ncbi pathways :

FoxO Signaling Pathway (921162); GABAergic Synapse Pathway (377263); GABAergic Synapse Pathway (377129); Regulation Of Autophagy Pathway (83058); Regulation Of Autophagy Pathway (468); Senescence And Autophagy Pathway (198780)

ncbi summary :

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

uniprot summary :

GABARAP: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Belongs to the MAP1 LC3 family. Interacts with GPHN and NSF. Interacts with GABRG2, beta-tubulin and ULK1. Protein type: Autophagy; Ubiquitin-like modifier; Adaptor/scaffold; Microtubule-binding; Vesicle. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: microtubule; smooth endoplasmic reticulum; lysosome; autophagic vacuole; cytosol; actin cytoskeleton; Golgi membrane; microtubule associated complex; extrinsic to membrane; perinuclear region of cytoplasm; plasma membrane; axoneme; cytoplasmic vesicle. Molecular Function: protein binding; microtubule binding; beta-tubulin binding; GABA receptor binding. Biological Process: synaptic transmission; induction of apoptosis via death domain receptors; mitochondrion degradation; microtubule cytoskeleton organization and biogenesis; protein targeting; autophagic vacuole formation

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

205

size3 :

1 mg

price3 :

2220

more info or order :

MyBioSource product webpage