catalog number :
MBS143620
products type :
Recombinant Protein
products full name :
Recombinant Human TBP-Like 1
products short name :
TBP-Like 1
products name syn :
TBPL1 Human; TBP-Like 1 Human Recombinant; TATA box-binding protein-like protein 1; TBP-like protein 1; 21 kDa TBP-like protein; Second TBP of unique DNA protein; STUD; TATA box-binding protein-related factor 2; TBP-related factor 2; TBP-like factor; TBP-related protein; TBPL1; TLF; TLP; TLP21; TRF2; TRP; MGC:8389; MGC:9620
other names :
TATA box-binding protein-like protein 1; TATA box-binding protein-like protein 1; TATA box-binding protein-like protein 1; 21-kDA TBP-like protein; TATA box-binding protein-related factor 2; TBP-related factor 2; TBP-related protein; second TBP of unique DNA protein; TBP-like 1; 21 kDa TBP-like protein; Second TBP of unique DNA protein; STUD; TATA box-binding protein-related factor 2; TBP-related factor 2; TBP-like factor; TBP-related protein
products gene name :
TBPL1
other gene names :
TBPL1; TBPL1; TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620; TLF; TLP; TLP21; TRF2; TRP; TBP-like protein 1; STUD; TBP-related factor 2
uniprot entry name :
TBPL1_HUMAN
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
TBPL1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT and 1mM EDTA. Sterile Filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
products description :
Description: TBPL1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 209 amino acids (1-186 a.a) and having a molecular mass of 23.3kDa.TBPL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: TBP-Like 1 (TBPL1) is a member of the TBP family. The TATA box-binding protein (TBP) is an indispensable component of the basal transcriptional machinery. TBPL1 is crucial for spermiogenesis and supposed to be significant in expression of developmentally regulated genes.
ncbi acc num :
NP_001240605.1
ncbi gb acc num :
NM_001253676.1
ncbi mol weight :
20,887 Da
ncbi pathways :
Basal Transcription Factors Pathway (83038); Basal Transcription Factors Pathway (443); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512)
ncbi summary :
This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
uniprot summary :
TBPL1: Does not bind the TATA box. Has DNA-binding ability. Belongs to the TBP family. Protein type: Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 6q23.2. Cellular Component: cytoplasm; transcription factor TFIIA complex. Molecular Function: DNA binding; transcription coactivator activity. Biological Process: acrosome formation; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription initiation; spermatid nuclear differentiation; dTTP biosynthetic process