protein

Recombinant Human Cell Division Cycle 42

MBS143611

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Cell Division Cycle 42

Cell Division Cycle 42

CDC42 Human; Cell Division Cycle 42 Human Recombinant; Cell division control protein 42 homolog; G25K GTP-binding protein; CDC42; G25K; CDC42Hs

cell division control protein 42 homolog isoform 1; Cell division control protein 42 homolog; cell division control protein 42 homolog; G25K GTP-binding protein; GTP binding protein, 25kDa; GTP-binding protein, 25kD; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); growth-regulating protein; small GTP binding protein CDC42; cell division cycle 42; G25K GTP-binding protein

CDC42

CDC42; CDC42; G25K; CDC42Hs

CDC42_HUMAN

E Coli

191

Greater than 95.0% as determined by SDS-PAGE.

The CDC42 solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT, 10% glycerol and 2mM EDTA. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Cell Division Cycle

Description: CDC42 Human Recombinant fused with a 15 amino acid T7 tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 203 amino acids (1-188 a.a.) and having a molecular mass of 22.4kDa.The CDC42 is purified by proprietary chromatographic techniques. Introduction: CDC42 (Cell division cycle 42 isoform 1) is a small GTPase of the Rho-subfamily that regulates signaling pathways which control various cellular functions including cell morphology, migration, endocytosis and cell cycle progression. CDC42 is a plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In the active state, CDC42 binds to a variety of effector proteins to regulate cellular responses. CDC42 is involved in epithelial cell polarization processes. CDC42 causes the formation of thin, actin-rich surface projections called filopodia. Also, CDC42 regulates actin polymerization through its direct binding to N-WASP (Neural Wiskott-Aldrich syndrome protein), which subsequently activates Arp2/3 complex. Loss of CDC42 function raises endocytotic uptake of apical proteins, as well as apical polarity factors such as Crumbs. The product of oncogene Dbl was described to specifically catalyze the dissociation of GDP from CDC42 protein.

89903012

NP_001034891.1

NM_001039802.1

P60953

21,311 Da

AGE/RAGE Pathway 698754!!Adaptive Immune System Pathway 366160!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Androgen Receptor Signaling Pathway 198806!!Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 105688!!BDNF Signaling Pathway 712093!!Bacterial Invasion Of Epithelial Cells Pathway 149807

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

0.01 mg

140 USD