Recombinant Human Monoamine Oxidase B | MyBioSource MBS143591 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Monoamine Oxidase B

catalog :

MBS143591

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143591

products type :

Recombinant Protein

products full name :

Recombinant Human Monoamine Oxidase B

products short name :

Monoamine Oxidase B

products name syn :

MAO B Human; Monoamine Oxidase B Human Recombinant; Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; MAOB; MGC26382

other names :

amine oxidase; Amine oxidase [flavin-containing] B; amine oxidase [flavin-containing] B; amine oxidase [flavin-containing] B; MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; monoamine oxidase B; Monoamine oxidase type B; MAO-B

products gene name :

MAO-B

other gene names :

MAOB; MAOB; MAO-B

uniprot entry name :

AOFB_HUMAN

host :

E Coli

sequence length :

520

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

MAO-B protein is supplied in 20mM Tris-HCl, pH 8.0, 250mM NaCl, 1mM EDTA and 50% glycerol. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.

products categories :

ENZYMES; Enzymes; Oxidase

products description :

Description: MAO-B Human Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 488 amino acids fragment (2-489) corresponding to the cytoplasmic domain fragment of the mature protein, having a total molecular mass of 59.84kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The MAO-B is purified by proprietary chromatographic techniques. Introduction: MAO-B is a member of the flavin monoamine oxidase family. MAO-B (Monoamine oxidase B) is a flavin-containing mitochondrial enzyme that catalyzes the oxidative deamination of biogenic and xenobiotic monoamines. MAO-B controls the metabolic degradation of catecholamines and serotonin in neural and other target tissues. MAO-B is located in platelets and in dopamine-secreting neurons in the brain. MAOB and MAOA genes have an imperative function in dopamine degradation. Benzylamine and phenylethylamine are preferentially degraded by MAOB. The MAOB gene is linked to autistic traits, empathy and Asperger syndrome. Amplified levels of MAO B are identified in the brain of Alzheimer's patients. High phenylethylamine levels in neonates as a result of low MAOB are consistent with phenylketonuria in newborns. Polymorphisms in MAO-B are connected to smoking behavior.

ncbi gi num :

38202207

ncbi acc num :

NP_000889.3

ncbi gb acc num :

NM_000898.4

uniprot acc num :

P27338

ncbi mol weight :

46,539 Da

ncbi pathways :

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alpha-synuclein Signaling Pathway (137913); Amine Oxidase Reactions Pathway (105712); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Biogenic Amines Are Oxidatively Deaminated To Aldehydes By MAOA And MAOB Pathway (105713); Biological Oxidations Pathway (105698)

ncbi summary :

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

uniprot summary :

MAOB: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family. Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - glycine, serine and threonine; Membrane protein, integral; EC 1.4.3.4; Mitochondrial; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine. Chromosomal Location of Human Ortholog: Xp11.23. Cellular Component: mitochondrial envelope; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane. Molecular Function: amine oxidase activity; protein homodimerization activity; FAD binding; electron carrier activity. Biological Process: response to drug; negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; response to selenium ion; response to ethanol; substantia nigra development; dopamine catabolic process; response to toxin; xenobiotic metabolic process; response to lipopolysaccharide; hydrogen peroxide biosynthetic process; response to aluminum ion; response to corticosterone stimulus

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4630

more info or order :

MyBioSource product webpage