protein

Recombinant Human 4-1BB Ligand, His Tag

MBS143574

0.02 mg

205 USD

Recombinant Protein

Recombinant Human 4-1BB Ligand, His Tag

4-1BB Ligand

4 1BBL Human, His; 4-1BB Ligand Human Recombinant, His Tag; CD137L; CD137-L; 4-1BBL; 4-1BB Ligand; TNFSF9; Tumor Necrosis Factor (ligand) Superfamily Member 9; 4 1BBL, His

tumor necrosis factor ligand superfamily member 9; Tumor necrosis factor ligand superfamily member 9; tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; tumor necrosis factor (ligand) superfamily, member 9; 4-1BB ligand; 4-1BBL

4 1BBL

TNFSF9; TNFSF9; CD137L; 4-1BB-L; 4-1BBL

TNFL9_HUMAN

E Coli

254

Greater than 95.0% as determined by SDS-PAGE

Recombinant 4-1BBL solution (1mg/ml) contains 20mM Tris-HCl buffer pH-8, 100mM NaCl and 20% glycerol. Sterile Filtered colorless solution.

CYTOKINES AND GROWTH FACTORS; Cytokines

Description: TNFSF9 Human Recombinant fused to 37 amino acids His tag at N-terminus produced in E Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (71-254 a.a.) and having a molecular mass of 23.8 kDa. The TNFSF9 37 aa His tag fusion protein is purified by proprietary chromatographic techniques. Introduction: 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin

4507609

NP_003802.1

NM_003811.3

P41273

26,625 Da

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

0.02 mg

205 USD