protein

Recombinant Human Carbonyl Reductase-3

MBS143571

0.02 mg

205 USD

Recombinant Protein

Recombinant Human Carbonyl Reductase-3

Carbonyl Reductase-3

CBR3 Human; Carbonyl Reductase-3 Human Recombinant; Carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3; CBR3; carbonyl reductase 3; hCBR3; SDR21C2

carbonyl reductase; Carbonyl reductase [NADPH] 3; carbonyl reductase [NADPH] 3; carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3; carbonyl reductase (NADPH) 3; epididymis secretory protein Li 25; short chain dehydrogenase/reductase family 21C, member 2; carbonyl reductase 3; NADPH-dependent carbonyl reductase 3

CBR3

CBR3; CBR3; hCBR3; SDR21C2; HEL-S-25

CBR3_HUMAN

E Coli

277

MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW.

Greater than 95.0% as determined by analysis by SDS-PAGE.

The CBR3 protein contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

ENZYMES; Enzymes; Reductase

Description: Recombinant Human CBR3 fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated polypeptide chain containing 297 amino acids (1-277 a.a) and having a molecular mass of 33kDa. CBR3 is purified by proprietary chromatographic techniques. Introduction: CBR3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. CBR3 is one of several monomeric NADPH-dependent oxidoreductases. Furthermore, CBR3 contains 3 exons spanning 11.2 kilobases and is strongly linked to another carbonyl reductase gene, the CBR1. It was suggested that CBR3 mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy.CBR3 is identified in the ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and the testis.Polymorphisms in CBR3 may give an explanation to interindividual and interethnic variability of doxorubicin pharmacokinetics and pharmacodynamics.

4502601

NP_001227.1

NM_001236.3

O75828

30,850 Da

Arachidonic Acid Metabolism Pathway 82991!!Arachidonic Acid Metabolism Pathway 366!!Metabolic Pathways 132956!!Metabolism Of Xenobiotics By Cytochrome P450 Pathway 83031!!Metabolism Of Xenobiotics By Cytochrome P450 Pathway 425

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]

0.02 mg

205 USD