catalog number :
MBS143569
products type :
Recombinant Protein
products full name :
Recombinant Human Eukaryotic Translation Initiation Factor 5A
products short name :
Eukaryotic Translation Initiation Factor 5A
products name syn :
EIF5A Human; Eukaryotic Translation Initiation Factor 5A Human Recombinant; EIF-5A; EIF5A1; eIF5AI; MGC99547; MGC104255; EIF5A; Eukaryotic translation initiation factor 5A-1; eIF-5A-1; eIF-5A1; Eukaryotic initiation factor 5A isoform 1; eIF-4D; Rev-binding factor
other names :
eukaryotic translation initiation factor 5A-1 isoform A; Eukaryotic translation initiation factor 5A-1; eukaryotic translation initiation factor 5A-1; eIF-4D; eIF-5A-1; eIF-5A1; eukaryotic initiation factor 5A; rev-binding factor; eukaryotic translation initiation factor 5A; Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D
products gene name :
EIF5A
other gene names :
EIF5A; EIF5A; EIF-5A; EIF5A1; eIF5AI; eIF-5A-1; eIF-5A1; eIF-5A
uniprot entry name :
IF5A1_HUMAN
sequence :
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVRE DLRLPEGDLG KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK.
purity :
Greater than 95.0% as determined by SDS-PAGE.
form :
The EIF5A protein solution contains 50mM Tris-HCl, pH-7.5 and 10% Glycerol. Sterile filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Eukaryotic Translation Initiation Factor
products description :
Description: EIF5A produced in E Coli is a single, non-glycosylated polypeptide chain containing 154 amino acids and having a molecular mass of 16.8 kDa. EIF5A is purified by proprietary chromatographic techniques. Introduction: EIF5A is the single protein identified to contain remarkable amino acid formed by the action of deoxyhypusine synthase and deoxyhypusine hydroxylase using spermidine as the substrate. EIF5A takes part in the first step of peptide bond formation in translation, nevertheless further experiments implicates it as a universally conserved translation elongation factor. Modulation of EIF5A is connected to proliferation and cancer. Expression of EIF-5A is upregulated in the PBMCs of HIV-1 patients. EIF5A coordinates significant cellular processes like cell viability and senescence during its effects on the stability of certain mRNAs. Heat stress-induced loss of EIF-5A in a human pancreatic cancer cell line. EIF5A stability takes part in determining the fate of the particular cell type after severe heat stress.
ncbi acc num :
NP_001137232.1
ncbi gb acc num :
NM_001143760.1
ncbi mol weight :
20,170 Da
ncbi pathways :
Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway 106231!!Hypusine Synthesis From EIF5A-lysine Pathway 106240!!Metabolism Of Proteins Pathway 106230!!Post-translational Protein Modification Pathway 161012!!Translation Factors Pathway 198803