protein

Recombinant Human Myosin Light Chain 2

MBS143565

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Myosin Light Chain 2

Myosin Light Chain 2

MYL2 Human; Myosin Light Chain 2 Human Recombinant; MLC2; CMH10; MYL-2; Myosin regulatory light chain 2; MYOSIN LIGHT CHAIN REGULATORY VENTRICULAR; DKFZp779C0562; MYL2; MLC-2v; MLC-2

myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2; MLC-2v; RLC of myosin; cardiac ventricular myosin light chain 2; myosin, light polypeptide 2, regulatory, cardiac, slow; regulatory light chain of myosin; slow cardiac myosin regulatory light chain 2; myosin, light chain 2, regulatory, cardiac, slow

MYL2

MYL2; MYL2; MLC2; CMH10; MLC-2; MLC-2v

MLRV_HUMAN

E Coli

166

MGSSHHHHHH SSGLVPRGSH MAPKKAKKRA GGANSNVFSM FEQTQIQEFK EAFTIMDQNR DGFIDKNDLR DTFAALGRVN VKNEEIDEMI KEAPGPINFT VFLTMFGEKL KGADPEETIL NAFKVFDPEG KGVLKADYVR EMLTTQAERF SKEEVDQMFA AFPPDVTGNL DYKNLVHIIT HGEEKD.

Greater than 95.0% as determined by SDS-PAGE.

MYL2 solution containing 20mM Tris pH-8 pH-7.4, 20% glycerol and 5mM CaCl2. Sterile filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Myosin Light Chain

Description: MYL2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 186 amino acids (1-166) and having a molecular mass of 20.9 kDa. MYL2 is fused to a 20 amino acid His Tag fused at N-terminus and purified by proprietary chromatographic techniques. Introduction: MYL2 regulatory light chain is associated with cardiac myosin beta (or slow) heavy chain. Ca+ activates the phosphorylation of regulatory light chain that in turn activates contraction. Mutations in this MYL2 gene are related with mid-left ventricular chamber type hypertrophic cardiomyopathy. MYL2 is an essential protein that plays a role in the regulation of myosin ATPase activity in smooth muscle. MYL2 phosphorylation is regulated by ROCK and MLC kinase and is involved in platelet biogenesis by controlling proplatelet formation and fragmentation.

94981553

NP_000423.2

NM_000432.3

P10916

18,789 Da

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); CDC42 Signaling Events Pathway (137994); Cardiac Progenitor Differentiation Pathway (712094); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478)

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. Protein type: Contractile. Chromosomal Location of Human Ortholog: 12q24.11. Cellular Component: sarcomere; cytoskeleton; myofibril; cytosol; myosin complex; A band; actin cytoskeleton. Molecular Function: actin monomer binding; protein binding; structural constituent of muscle; calcium ion binding; myosin heavy chain binding. Biological Process: muscle cell fate specification; heart contraction; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; cardiac muscle contraction; post-embryonic development; muscle filament sliding. Disease: Cardiomyopathy, Familial Hypertrophic, 10

0.005 mg

140 USD

0.025 mg

205

1 mg

2920