protein

Recombinant Human Dickkopf-Related Protein 1

MBS143555

0.01 mg

530 USD

Recombinant Protein

Recombinant Human Dickkopf-Related Protein 1

Dickkopf-Related Protein 1

DKK1 Human; Dickkopf-Related Protein 1 Human Recombinant; DKK-1; DKK1; HDKK1; HDKK-1; Dickkopf-1; Dickkopf-related protein 1; SK

dickkopf-related protein 1; Dickkopf-related protein 1; dickkopf-related protein 1; dickkopf 1 homolog; dickkopf related protein-1; dickkopf-1 like; dickkopf-like protein 1; hDkk-1; dickkopf WNT signaling pathway inhibitor 1; SK

DKK1

DKK1; DKK1; SK; DKK-1; Dickkopf-1; Dkk-1; hDkk-1

DKK1_HUMAN

Hi-5 Baculovirus

266

Greater than 85.0% as determined by SDS-PAGE.

The DKK1 protein solution (0.25mg/ml) contains PBS (pH 7.4) and 10% Glycerol. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Dickkopf-Related Protein

Description: DKK1 produced in Hi-5 is a single, glycosylated polypeptide chain containing 253 amino acids (32-266 a.a.) and having a molecular mass of 27.8 kDa.DKK1 is expressed with a 15 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques. Introduction: DKK1 is part of the dickkopf family. DKK1 is a secreted protein with 2 cysteine rich regions and takes part in embryonic development through its inhibition of the WNT signaling pathway. High levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Induction of DKK1 contributes to the pathological cascade triggered by beta-amyloid and is significantly involved in the development of tau phosphorylation. DKK1 reduces the differentiation of osteoblastic precursor cells. DKK1 is an important member in multiple myeloma bone disease. DKK1 expression is reduced in human colon tumors, implying that DKK-1 plays a role as a tumor suppressor gene in this neoplasia; the Wnt/beta-catenin pathway is downregulated by the induction of DKK1 expression, a mechanism that is missing in colon cancer.

7110719

NP_036374.1

NM_012242.2

O94907

28,672 Da

Cardiac Progenitor Differentiation Pathway 712094!!Direct P53 Effectors Pathway 137939!!Disease Pathway 530764!!Presenilin Action In Notch And Wnt Signaling Pathway 137914!!RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway 1127632!!Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway 169352!!Signal Transduction Pathway 477114!!Signaling By WNT In Cancer Pathway 1127614!!Signaling By Wnt Pathway 106510!!TCF Dependent Signaling In Response To WNT Pathway 1127516

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

0.01 mg

530 USD