Human Glucagon Like Peptide-2 | MyBioSource MBS143551 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Glucagon Like Peptide-2

catalog :

MBS143551

quantity :

1 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143551

products type :

Native Protein

products full name :

Human Glucagon Like Peptide-2

products short name :

Glucagon Like Peptide-2

products name syn :

GLP 2 Human; Human Glucagon Like Peptide-2; GLP2; GLP-2; Glucagon Like Peptide-2

other names :

glucagon preproprotein; Glucagon; glucagon; glicentin-related polypeptide; glucagon-like peptide 1; glucagon-like peptide 2; preproglucagon; glucagon; Incretin hormone

products gene name :

GLP 2

other gene names :

GCG; GCG; GLP1; GLP2; GRPP; GRPP; OXM; OXY; GLP-1; GLP-1(7-37); GLP-1(7-36); GLP-2

uniprot entry name :

GLUC_HUMAN

sequence length :

180

sequence :

His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-Arg.

purity :

Greater than 95.0% as determined by RP-HPLC.

form :

The protein (1mg/ml) was lyophilized with no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized GLP2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution GLP2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized GLP-2 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

products categories :

HORMONES; Hormones; GLP

products description :

Description: Glucagon Like Peptide-2 contains 34 amino acids having a molecular mass of 3922.38 Dalton. Introduction: GLP-2 functions as an intestinal growth factor, which stimulates intestinal epithelial growth. GLP2 is involved in diabetes-associated bowel growth. GLP2 enhances cell differentiation, playing a role as a cytokine and in tissue regeneration, and mediating cytoprotection. GLP2 is invloded numerous therapeutic applications. GLP2 regulates signaling pathways coupled to cell proliferation and cell death by apoptosis.GLP-2 is produced by specific post-translational proteolytic cleavage of proglucagon GLP-2 is manufactured by the intestinal endocrine L cell and by several neurons in the central nervous system.

ncbi gi num :

4503945

ncbi acc num :

NP_002045.1

ncbi gb acc num :

NM_002054.4

uniprot acc num :

P01275

ncbi mol weight :

20,909 Da

ncbi pathways :

Class B/2 (Secretin Family Receptors) Pathway (106378); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); FOXA1 Transcription Factor Network Pathway (137979); G Alpha (q) Signalling Events Pathway (106043); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Glucagon Signaling In Metabolic Regulation Pathway (106097)

ncbi summary :

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]

uniprot summary :

GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family. Protein type: Hormone; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2q36-q37. Cellular Component: extracellular space; endoplasmic reticulum lumen; plasma membrane; extracellular region. Molecular Function: identical protein binding; protein binding; hormone activity; glucagon receptor binding; receptor binding. Biological Process: positive regulation of protein binding; positive regulation of histone H3-K4 methylation; signal transduction; positive regulation of peptidyl-serine phosphorylation; response to starvation; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; cell proliferation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; feeding behavior; regulation of insulin secretion; negative regulation of apoptosis

size1 :

1 mg

price1 :

140 USD

size2 :

5 mg

price2 :

205

size3 :

100 mg

price3 :

1935

more info or order :

MyBioSource product webpage